Gene expression and copy number profiling of follicular lymphoma biopsies from patients treated with first-line rituximab without chemotherapy

Leich, E. (author): Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Wurzburg, Germany.

Schmidt, T. (author): Univ Regensburg, Inst Funct Genom, Stat Bioinformat, Regensburg, Germany.

Altenbuchinger, M. (author): Univ Regensburg, Inst Funct Genom, Stat Bioinformat, Regensburg, Germany.;Univ Med Ctr Gottingen, Dept Med Bioinformat, Gottingen, Germany.

Lingjaerde, Ole Christian (author): Univ Oslo, Dept Comp Sci, Div Biomed Informat, N-0316 Oslo, Norway.

Lockmer, S. (author): Karolinska Inst, Dept Med Huddinge, Div Hematol, Stockholm, Sweden.

Nedeva, T. (author): Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Wurzburg, Germany.

Grieb, T. (author): Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Wurzburg, Germany.

Sander, B. (author): Karolinska Institutet,Karolinska Inst, Dept Lab Med, Div Pathol, Stockholm, Sweden.

Spang, R. (author): Univ Regensburg, Inst Funct Genom, Stat Bioinformat, Regensburg, Germany.

Kimby, E. (author): Karolinska Inst, Dept Med Huddinge, Div Hematol, Stockholm, Sweden.

Rosenwald, A. (author): Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Wurzburg, Germany.;Univ Wurzburg, Inst Pathol, Josef Schneider Str 2, D-97080 Wurzburg, Germany.

Univ Wurzburg, Comprehens Canc Ctr Mainfranken, Inst Pathol, Wurzburg, Germany Oslo Univ Hosp, Dept Oncol, Oslo, Norway. (creator_code:org_t)

Taylor & Francis, 2023
2023
English.
In: Leukemia and Lymphoma. - : Taylor & Francis. - 1042-8194 .- 1029-2403. ; 64:12, s. 1927-1937

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

The Nordic Lymphoma Study Group has performed two randomized clinical trials with chemotherapy-free first-line treatment (rituximab +/- interferon) in follicular lymphoma (FL), with 73% of patients alive and 38% without any need of chemotherapy after 10.6 years median follow-up. In order to identify predictive markers, that may also serve as therapeutic targets, gene expression- and copy number profiles were obtained from 97 FL patients using whole genome microarrays. Copy number alterations (CNAs) were identified, e.g. by GISTIC. Cox Lasso Regression and Lasso logistic regression were used to determine molecular features predictive of time to next therapy (TTNT). A few molecular changes were associated with TTNT (e.g. increased expression of INPP5B, gains in 12q23/q24), but were not significant after adjusting for multiple testing. Our findings suggest that there are no strong determinants of patient outcome with respect to GE data and CNAs in FL patients treated with a chemotherapy-free regimen (i.e. rituximab +/- interferon).

By the author/editor: Leich, E.; Brodtkorb, Maria ...; Schmidt, T.; Altenbuchinger, ...; Lingjaerde, Ole ...; Lockmer, S.; show more...; Holte, H.; Nedeva, T.; Grieb, T.; Sander, B.; Sundström, Chris ...; Spang, R.; Kimby, E.; Rosenwald, A.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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