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Prognostic signific...
Prognostic significance of chronic myocardial injury diagnosed by three different cardiac troponin assays in patients admitted with suspected acute coronary syndrome
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- Steiro, Ole-Thomas (author)
- Haukeland Hosp, Dept Heart Dis, Jonas Lies vei 65, N-5021 Bergen, Norway.
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- Langorgen, Jorund (author)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
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- Tjora, Hilde L. (author)
- Haukeland Hosp, Emergency Care Clin, Bergen, Norway.
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- Bjorneklett, Rune O. (author)
- Haukeland Hosp, Emergency Care Clin, Bergen, Norway.;Univ Bergen, Dept Clin Med, Bergen, Norway.
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- Skadberg, Oyvind (author)
- Stavanger Univ Hosp, Lab Med Biochem, Stavanger, Norway.
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- Bonarjee, Vernon V. S. (author)
- Stavanger Univ Hosp, Dept Cardiol, Stavanger, Norway.
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- Mjelva, Oistein R. (author)
- Stavanger Univ Hosp, Dept Internal Med, Stavanger, Norway.
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- Steinsvik, Trude (author)
- Vestre Viken Hosp Trust, Dept Lab Med, Baerum, Norway.
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Omland, Torbjorn (author)
- Univ Oslo, Inst Clin Med, Ctr Heart Failure Res, Oslo, Norway.;Akershus Univ Hosp, Dept Cardiol, Oslo, Norway.
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- Aakre, Kristin M. (author)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Bergen, Norway.
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- Vikenes, Kjell (author)
- Haukeland Hosp, Dept Heart Dis, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.
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Haukeland Hosp, Dept Heart Dis, Jonas Lies vei 65, N-5021 Bergen, Norway Haukeland Hosp, Dept Heart Dis, Bergen, Norway. (creator_code:org_t)
- Walter de Gruyter, 2024
- 2024
- English.
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In: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 62:4, s. 729-739
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Abstract
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- Objectives:Chronic myocardial injury (CMI) is defined as stable concentrations of cardiac troponin T or I (cTnT or cTnI) above the assay-specific 99th percentile upper reference limit (URL) and signals poor outcome. The clinical implications of diagnosing CMI are unclear. We aimed to assess prevalence and association of CMI with long-term prognosis using three different high-sensitivity cTn (hs-cTn) assays.Methods:A total of 1,292 hospitalized patients without acute myocardial injury had cTn concentrations quantified by hs-cTn assays by Roche Diagnostics, Abbott Diagnostics and Siemens Healthineers. The median follow-up time was 4.1 years. The prevalence of CMI and hazard ratios for mortality and cardiovascular (CV) events were calculated based on the URL provided by the manufacturers and compared to the prognostic accuracy when lower percentiles of cTn (97.5, 95 or 90), limit of detection or the estimated bioequivalent concentrations between assays were used as cutoff values.Results:There was no major difference in prognostic accuracy between cTnT and cTnI analyzed as continuous variables. The correlation between cTnT and cTnI was high (r=0.724-0.785), but the cTnT assay diagnosed 3.9-4.5 times more patients with having CMI based on the sex-specific URLs (TnT, n=207; TnI Abbott, n=46, TnI Siemens, n=53) and had higher clinical sensitivity and AUC at the URL.Conclusions:The prevalence of CMI is highly assay-dependent. cTnT and cTnI have similar prognostic accuracy for mortality or CV events when measured as continuous variables. However, a CMI diagnosis according to cTnT has higher prognostic accuracy compared to a CMI diagnosis according to cTnI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- cardiac troponin T
- cardiac troponin I
- chronic myocardial injury
- 99th percentile
- prognostic accuracy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Steiro, Ole-Thom ...
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Langorgen, Jorun ...
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Tjora, Hilde L.
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Bjorneklett, Run ...
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Skadberg, Oyvind
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Bonarjee, Vernon ...
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Mjelva, Oistein ...
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Steinsvik, Trude
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Lindahl, Bertil, ...
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Omland, Torbjorn
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Aakre, Kristin M ...
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Vikenes, Kjell
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Uppsala University