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Cellular architectu...
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology
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- Kukanja, Petra (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden.
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- Langseth, Christoffer M. (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Rodriguez-Kirby, Leslie A. Rubio (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden.
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- Agirre, Eneritz (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden.
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- Zheng, Chao (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden.
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- Raman, Amitha (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Yokota, Chika (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Avenel, Christophe (author)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Science for Life Laboratory, SciLifeLab
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- Tiklova, Katarina (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Guerreiro-Cacais, Andre O. (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Clin Neurosci, Ctr Mol Med, S-17176 Solna, Sweden.
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- Olsson, Tomas (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Dept Clin Neurosci, Ctr Mol Med, S-17176 Solna, Sweden.
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- Hilscher, Markus M. (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Nilsson, Mats (author)
- Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, S-17154 Stockholm, Sweden.
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- Castelo-Branco, Goncalo (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, Biomedicum, S-17177 Stockholm, Sweden (creator_code:org_t)
- Cell Press, 2024
- 2024
- English.
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In: Cell. - : Cell Press. - 0092-8674 .- 1097-4172. ; 187:8, s. 1990-2009
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Abstract
Subject headings
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- Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and smoldering pathology. Although single -cell analyses provided insights into cytopathology, evolving cellular processes underlying MS remain poorly understood. We investigated the cellular dynamics of MS by modeling temporal and regional rates of disease progression in mouse experimental autoimmune encephalomyelitis (EAE). By performing single -cell spatial expression profiling using in situ sequencing (ISS), we annotated disease neighborhoods and found centrifugal evolution of active lesions. We demonstrated that disease -associated (DA)-glia arise independently of lesions and are dynamically induced and resolved over the disease course. Single -cell spatial mapping of human archival MS spinal cords confirmed the differential distribution of homeostatic and DA-glia, enabled deconvolution of active and inactive lesions into sub -compartments, and identified new lesion areas. By establishing a spatial resource of mouse and human MS neuropathology at a single -cell resolution, our study unveils the intricate cellular dynamics underlying MS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- spatial sequencing
- in situ sequencing
- single-cell
- experimental autoimmune
- encephalomyelitis
- EAE
- multiple sclerosis
- MS
- neuropathology
- neuroinflammation disease-associated glia
- Serpina3n
- SERPINA3
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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- By the author/editor
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Kukanja, Petra
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Langseth, Christ ...
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Rodriguez-Kirby, ...
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Agirre, Eneritz
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Zheng, Chao
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Raman, Amitha
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show more...
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Yokota, Chika
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Avenel, Christop ...
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Tiklova, Katarin ...
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Guerreiro-Cacais ...
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Olsson, Tomas
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Hilscher, Markus ...
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Nilsson, Mats
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Castelo-Branco, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Cell
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Uppsala University
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Karolinska Institutet