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The Pattern of GH A...
The Pattern of GH Action in the Mouse Brain
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- Menezes, Filipe (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil.
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- Wasinski, Frederick (author)
- Univ Sao Paulo, Dept Fisiol & Biofis, Inst Ciencias Biomed, BR-05508000 Sao Paulo, Brazil.;Univ Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil.
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- de Souza, Gabriel O. (author)
- Univ Sao Paulo, Dept Fisiol & Biofis, Inst Ciencias Biomed, BR-05508000 Sao Paulo, Brazil.
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- Nunes, Amanda P. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil.
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- Bernardes, Emerson S. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Radiopharm Ctr, BR-05508000 Sao Paulo, Brazil.
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- dos Santos, Sofia N. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Radiopharm Ctr, BR-05508000 Sao Paulo, Brazil.
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- da Silva, Fabio F. A. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Radiopharm Ctr, BR-05508000 Sao Paulo, Brazil.
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- Peroni, Cibele N. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil.
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- Oliveira, Joao E. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil.
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- Kopchick, John J. (author)
- Ohio Univ, Edison Biotechnol Inst, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
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- Brown, Rosemary S. E. (author)
- Univ Otago, Ctr Neuroendocrinol, Sch Biomed Sci, Dept Physiol, Dunedin 9054, New Zealand.
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- Fernandez, Gimena (author)
- Multidisciplinary Inst Cell Biol, Lab Neurophysiol, RA-1900 La Plata, BA, Argentina.
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- De Francesco, Pablo N. (author)
- Multidisciplinary Inst Cell Biol, Lab Neurophysiol, RA-1900 La Plata, BA, Argentina.
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- Perello, Mario (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap,Multidisciplinary Inst Cell Biol, Lab Neurophysiol, RA-1900 La Plata, BA, Argentina.
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- Soares, Carlos R. J. (author)
- IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil.
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- Donato Jr, Jose (author)
- Univ Sao Paulo, Dept Fisiol & Biofis, Inst Ciencias Biomed, BR-05508000 Sao Paulo, Brazil.;Univ Sao Paulo, Inst Ciencias Biomed, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo, Brazil.
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IPEN CNEN SP, Inst Pesquisas Energet & Nucl, Biotechnol Ctr, BR-05508000 Sao Paulo, Brazil Univ Sao Paulo, Dept Fisiol & Biofis, Inst Ciencias Biomed, BR-05508000 Sao Paulo, Brazil.;Univ Fed Sao Paulo, Dept Neurol & Neurosurg, BR-04039032 Sao Paulo, Brazil. (creator_code:org_t)
- The Endocrine Society, 2024
- 2024
- English.
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In: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 165:7
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- GH acts in numerous organs expressing the GH receptor (GHR), including the brain. However, the mechanisms behind the brain's permeability to GH and how this hormone accesses different brain regions remain unclear. It is well-known that an acute GH administration induces phosphorylation of the signal transducer and activator of transcription 5 (pSTAT5) in the mouse brain. Thus, the pattern of pSTAT5 immunoreactive cells was analyzed at different time points after IP or intracerebroventricular GH injections. After a systemic GH injection, the first cells expressing pSTAT5 were those near circumventricular organs, such as arcuate nucleus neurons adjacent to the median eminence. Both systemic and central GH injections induced a medial-to-lateral pattern of pSTAT5 immunoreactivity over time because GH-responsive cells were initially observed in periventricular areas and were progressively detected in lateral brain structures. Very few choroid plexus cells exhibited GH-induced pSTAT5. Additionally, Ghr mRNA was poorly expressed in the mouse choroid plexus. In contrast, some tanycytes lining the floor of the third ventricle expressed Ghr mRNA and exhibited GH-induced pSTAT5. The transport of radiolabeled GH into the hypothalamus did not differ between wild-type and dwarf Ghr knockout mice, indicating that GH transport into the mouse brain is GHR independent. Also, single-photon emission computed tomography confirmed that radiolabeled GH rapidly reaches the ventral part of the tuberal hypothalamus. In conclusion, our study provides novel and valuable information about the pattern and mechanisms behind GH transport into the mouse brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- blood-brain barrier
- circumventricular organs
- GH
- hypothalamus
- neuroendocrinology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Menezes, Filipe
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Wasinski, Freder ...
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de Souza, Gabrie ...
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Nunes, Amanda P.
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Bernardes, Emers ...
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dos Santos, Sofi ...
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show more...
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da Silva, Fabio ...
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Peroni, Cibele N ...
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Oliveira, Joao E ...
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Kopchick, John J ...
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Brown, Rosemary ...
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Fernandez, Gimen ...
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De Francesco, Pa ...
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Perello, Mario
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Soares, Carlos R ...
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Donato Jr, Jose
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Endocrinology
- By the university
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Uppsala University