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The impact of sex o...
The impact of sex on treatment and outcome in relation to histological subtype in patients with resectable gastric cancer : Results from the randomized CRITICS trial
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- Caspers, Irene A. (author)
- Netherlands Canc Inst, Dept Gastrointestinal Oncol, Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.;Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands.
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- Slagter, Astrid E. (author)
- Netherlands Canc Inst, Antoni van Leeuwenhoek, Dept Radiat Oncol, Amsterdam, Netherlands.
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- Lind, Pehr (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.
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- Sikorska, Karolina (author)
- Netherlands Canc Inst, Dept Biometr, Antoni van Leeuwenhoek, Amsterdam, Netherlands.
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- Wiklund, Katja (author)
- Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden.
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- Pontén, Fredrik (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Nordsmark, Marianne (author)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
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- van de Velde, Cornelis J. H. (author)
- Leiden Univ, Dept Surg Oncol, Med Ctr, Leiden, Netherlands.
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- Meershoek-Klein Kranenbarg, Elma (author)
- Leiden Univ, Dept Surg Oncol, Med Ctr, Leiden, Netherlands.
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- van Sandick, Johanna W. (author)
- Netherlands Canc Inst, Dept Surg Oncol, Antoni Van Leeuwenhoek, Amsterdam, Netherlands.
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- Jansen, Edwin P. M. (author)
- Netherlands Canc Inst, Antoni van Leeuwenhoek, Dept Radiat Oncol, Amsterdam, Netherlands.
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- van Laarhoven, Hanneke W. M. (author)
- Univ Amsterdam, Med Ctr, Dept Med Oncol, Amsterdam, Netherlands.
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- Verheij, Marcel (author)
- Netherlands Canc Inst, Antoni van Leeuwenhoek, Dept Radiat Oncol, Amsterdam, Netherlands.;Radboud Univ Nijmegen, Med Ctr, Dept Radiat Oncol, Nijmegen, Netherlands.
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- van Grieken, Nicole C. T. (author)
- Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands.
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- Cats, Annemieke (author)
- Netherlands Canc Inst, Dept Gastrointestinal Oncol, Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
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Netherlands Canc Inst, Dept Gastrointestinal Oncol, Antoni van Leeuwenhoek, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands;Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands. Netherlands Canc Inst, Antoni van Leeuwenhoek, Dept Radiat Oncol, Amsterdam, Netherlands. (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Journal of Surgical Oncology. - : John Wiley & Sons. - 0022-4790 .- 1096-9098. ; 129:4, s. 734-744
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and ObjectiveThis study aims to investigate the impact of sex on outcome measures stratified by histological subtype in patients with resectable gastric cancer (GC).MethodsA post-hoc analysis of the CRITICS-trial, in which patients with resectable GC were treated with perioperative therapy, was performed. Histopathological characteristics and survival were evaluated for males and females stratified for histological subtype (intestinal/diffuse). Additionally, therapy-related toxicity and compliance were compared.ResultsData from 781 patients (523 males) were available for analyses. Female sex was associated with a distal tumor localization in intestinal (p = 0.014) and diffuse tumors (p < 0.001), and younger age in diffuse GC (p = 0.035). In diffuse GC, tumor-positive resection margins were also more common in females than males (21% vs. 10%; p = 0.020), specifically at the duodenal margin. During preoperative chemotherapy, severe toxicity occurred in 327 (63%) males and 184 (71%) females (p = 0.015). Notwithstanding this, relative dose intensities were not significantly different between sexes.ConclusionsPositive distal margin rates were higher in females with diffuse GC, predominantly at the duodenal site. Females also experience more toxicity, but this neither impacts dose intensities nor surgical resection rates. Clinicians should be aware of these different surgical outcomes when treating males and females with GC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- gastric cancer
- histopathology
- Lauren classification
- sex
- sex differences
Publication and Content Type
- ref (subject category)
- art (subject category)
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Caspers, Irene A ...
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Slagter, Astrid ...
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Lind, Pehr
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Sikorska, Karoli ...
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Wiklund, Katja
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Pontén, Fredrik
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Nordsmark, Maria ...
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van de Velde, Co ...
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Meershoek-Klein ...
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van Sandick, Joh ...
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Jansen, Edwin P. ...
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van Laarhoven, H ...
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Verheij, Marcel
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van Grieken, Nic ...
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Cats, Annemieke
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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MEDICAL AND HEAL ...
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Journal of Surgi ...
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Uppsala University
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Karolinska Institutet