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  • Raza, Ghulam ShereUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)

Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • John Wiley & Sons,2024
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-531653
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531653URI
  • https://doi.org/10.1002/mnfr.202300465DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Scope: Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.Methods and resultsMale C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min(-1) alternate days for 9 weeks and 16 m min(-1) daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erb alpha in the liver, adipose tissue, and skeletal muscles. Conclusion: HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding.

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  • Kaya, YagmurIstanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye. (author)
  • Stenback, VilleUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)
  • Sharma, RavikantUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)
  • Sodum, NaliniUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)
  • Jagalur Mutt, ShivaprakashUppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)shija511 (author)
  • Gagnon, Dominique D.Univ Jyvaskyla, Fac Sports & Hlth Sci, Seminaarinkatu 15, Jyvaskyla 40014, Finland.;Univ Helsinki Makelankatu, Fac Med, Dept Sports & Exercise Med, Clin Sports & Exercise Med, Helsinki 00550, Finland. (author)
  • Tulppo, MikkoUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)
  • Jarvelin, Marjo-RiittaImperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW72AZ, England. (author)
  • Herzig, Karl-HeinzUniv Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.;Poznan Univ Med Sci, Pediat Inst, Pediat Gastroenterol & Metab Dis, PL-60572 Poznan, Poland. (author)
  • Makela, Kari A.Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland. (author)
  • Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.Istanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye. (creator_code:org_t)

Related titles

  • In:Molecular Nutrition & Food Research: John Wiley & Sons68:51613-41251613-4133

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