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Risk factors for No...
Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients : A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation
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- De Greef, Julien (author)
- Univ Catholique Louvain UCLouvain, Dept Internal Med & Infect Dis, Clin Univ St Luc, Brussels, Belgium.
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- Averbuch, Dina (author)
- Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Pediat Infect Dis, Jerusalem, Israel.
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- Tondeur, Laura (author)
- Univ Paris Cite, Inst Pasteur, Emerging Dis Epidemiol Unit, F-75015 Paris, France.
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- Duréault, Amélie (author)
- Univ Paris 05, Hop Necker Enfants Malad, AP HP, Ctr Infectiol Necker Pasteur, Paris, France.
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- Zuckerman, Tsila (author)
- Rambam Hlth Care Campus, H_efa, Israel.;Technion Israel Inst Technol, Rappaport Fac Med, H_efa, Israel.
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- Roussel, Xavier (author)
- Univ Franche Comte, Besancon Univ Hosp, Dept Hematol, INSERM,UMR1098, Besancon, France.
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- Robin, Christine (author)
- Henri Mondor Univ Hosp, Dept Hematol, Creteil, France.
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- Xhaard, Alienor (author)
- Paris Diderot Univ, Hematol Transplantat, Hosp St Louis, Paris, France.
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- Pagliuca, Simona (author)
- Nancy Univ Hosp, Hematol Dept, Vandoeuvre Les Nancy, France.
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- Beguin, Yves (author)
- Ctr Hosp Univ Liege, Liege, Belgium.;Univ Liege, Liege, Belgium.
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- Botella-Garcia, Carmen (author)
- CHU Bordeaux, Bordeaux, France.
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- Khanna, Nina (author)
- CHU Bordeaux, Bordeaux, France.
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- Le Bourgeois, Amandine (author)
- CHU Nantes, Nantes, France.
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- Van Praet, Jens (author)
- Algemeen Ziekenhuis Sint Jan Brugge Oostende, Dept Nephrol & Infect Dis, Brugge, Belgium.
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- Ho, Aloysius (author)
- Singapore Gen Hosp, Singapore, Singapore.
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- Kröger, Nicolaus (author)
- Univ Med Ctr, Dept Stem Cell Transplantat, Hamburg, Germany.
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- Ducastelle Leprêtre, Sophie (author)
- Hosp Civils Lyon, Hop Lyon Sud, Pierre Benite, France.
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- Roos-Weil, Damien (author)
- Sorbonne Univ, Hop Pitie Salpetriere, Paris, France.
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- Aljurf, Mahmoud (author)
- King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia.
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- Blijlevens, Nicole (author)
- Radboud Univ Nijmegen Med Ctr, Dept Hematol, Nijmegen, Netherlands.
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- Blau, Igor Wolfgang (author)
- Campus Virchow Klinikum CVK, Berlin, Germany.
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- Carlson, Kristina (author)
- Dept of Haematology, University Hospital, Uppsala, Sweden
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- Collin, Matthew (author)
- Bone Marrow Transplantat Freeman Hosp, Adult HSCT Unit, Nordern Ctr, Newcastle Upon Tyne, England.
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- Ganser, Arnold (author)
- Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpla, Hannover, Germany.
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- Villate, Alban (author)
- Univ Tours, CHU Tours, Serv Hematol & Therapie Cellulaire, Tours, France.
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- Lakner, Johannes (author)
- Univ Med Ctr, Med Clin 3, Rostock, Germany.
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- Martin, Sonja (author)
- Robert Bosch Krankenhaus, Stuttgart, Germany.
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- Nagler, Arnon (author)
- Chaim Sheba Med Ctr, Tel Hashomer, Israel.
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- Ram, Ron (author)
- Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.;Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
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- Torrent, Anna (author)
- ICO Hosp Germans Trias i Pujol, Josep Carreras Res Inst, Badalona, Spain.
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- Stamouli, Maria (author)
- Attikon Univ Gen Hosp, Athens, Greece.
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- Mikulska, Malgorzata (author)
- Univ Genoa, Dept Hlth Sci, Div Infect Dis, Genoa, Italy.;IRCCS Osped Policlin San Martino, Genoa, Italy.
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- Gil, Lidia (author)
- European Soc Blood & Marrow Transplantat EBMT, Leiden Study Unit, Leiden, Netherlands.
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- Wendel, Lotus (author)
- European Soc Blood & Marrow Transplantat EBMT, Leiden Study Unit, Leiden, Netherlands.
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- Tridello, Gloria (author)
- European Soc Blood & Marrow Transplantat EBMT, Leiden Study Unit, Leiden, Netherlands.
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- Knelange, Nina (author)
- Univ Basel, Div Infect Dis, Basel, Switzerland.;Univ Basel, Hosp Epidemiol, Basel, Switzerland.;Univ Hosp Basel, Basel, Switzerland.;European Soc Blood & Marrow Transplantat EBMT, Leiden Study Unit, Leiden, Netherlands.
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- de la Camara, Rafael (author)
- Hosp Princesa, Madrid, Spain.;EBMT, Infect Dis Working Party, Madrid, Spain.
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- Lortholary, Olivier (author)
- Univ Paris 05, Hop Necker Enfants Malad, AP HP, Ctr Infectiol Necker Pasteur, Paris, France.
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- Fontanet, Arnaud (author)
- Univ Paris Cite, Inst Pasteur, Emerging Dis Epidemiol Unit, F-75015 Paris, France.;Conservatoire Natl Arts & Metiers, Unite PACRI, F-75003 Paris, France.
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- Styczynski, Jan (author)
- Nicolaus Copernicus Univ Torun, Dept Pediat Hematol & Oncol, Coll Med, Bydgoszcz, Poland.
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- Maertens, Johan (author)
- Univ Ziekenhuizen Leuven, Dept Hematol, Leuven, Belgium.
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- Coussement, Julien (author)
- Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia.;CHU Guadeloupe, Serv Malad Infectieuses & Trop, Les Abymes, Guadeloupe, France.
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- Lebeaux, David (author)
- Univ Paris Cite, Inst Pasteur, Genet Biofilms Lab, CNRS,UMR 6047, F-75015 Paris, France.;Hop St Louis, Dept Malad Infectieuses & Trop, AP HP, F-75010 Lariboisiere, Paris, France.
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Univ Catholique Louvain UCLouvain, Dept Internal Med & Infect Dis, Clin Univ St Luc, Brussels, Belgium Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Pediat Infect Dis, Jerusalem, Israel. (creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Journal of Infection. - : Elsevier. - 0163-4453 .- 1532-2742. ; 88:6
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Abstract
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- ObjectivesNocardiosis is a rare but life-threatening infection after hematopoietic cell transplantation (HCT). We aimed at identifying risk factors for nocardiosis after allogeneic HCT and clarifying the effect of trimethoprim-sulfamethoxazole prophylaxis on its occurrence.MethodsWe performed a retrospective multicenter case-control study of patients diagnosed with nocardiosis after allogeneic HCT between January 2000 and December 2018. For each case, two controls were matched by center, transplant date, and age group. Multivariable analysis was conducted using conditional logistic regression to identify potential risk factors for nocardiosis. Kaplan-Meier survival curves of cases and controls were compared using log-rank tests.ResultsSixty-four cases and 128 controls were included. Nocardiosis occurred at a median of 9 months after allogeneic HCT (interquartile range: 5–18). After adjustment for potential confounders in a multivariable model, Nocardia infection was associated with tacrolimus use (adjusted odds ratio [aOR] 9.9, 95 % confidence interval [95 % CI]: 1.6–62.7), lymphocyte count < 500/µL (aOR 8.9, 95 % CI: 2.3–34.7), male sex (aOR 8.1, 95 % CI: 2.1–31.5), recent use of systemic corticosteroids (aOR 7.9, 95 % CI: 2.2–28.2), and recent CMV infection (aOR 4.3, 95 % CI: 1.2–15.9). Conversely, use of trimethoprim-sulfamethoxazole prophylaxis was associated with a significantly decreased risk of nocardiosis (aOR 0.2, 95 % CI: 0.1–0.8). HCT recipients who developed nocardiosis had a significantly decreased survival, as compared with controls (12-month survival: 58 % and 90 %, respectively; p < 0.0001).ConclusionsWe identified six factors independently associated with the occurrence of nocardiosis among allogeneic HCT recipients. In particular, trimethoprim-sulfamethoxazole prophylaxis was found to protect against nocardiosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Nocardiosis
- Hematopoietic stem cell transplantation
- HSCT
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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De Greef, Julien
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Averbuch, Dina
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Tondeur, Laura
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Duréault, Amélie
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Zuckerman, Tsila
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Roussel, Xavier
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show more...
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Robin, Christine
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Xhaard, Alienor
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Pagliuca, Simona
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Beguin, Yves
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Botella-Garcia, ...
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Khanna, Nina
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Le Bourgeois, Am ...
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Van Praet, Jens
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Ho, Aloysius
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Kröger, Nicolaus
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Ducastelle Leprê ...
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Roos-Weil, Damie ...
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Aljurf, Mahmoud
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Blijlevens, Nico ...
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Blau, Igor Wolfg ...
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Carlson, Kristin ...
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Collin, Matthew
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Ganser, Arnold
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Villate, Alban
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Lakner, Johannes
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Martin, Sonja
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Nagler, Arnon
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Ram, Ron
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Torrent, Anna
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Stamouli, Maria
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Mikulska, Malgor ...
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Gil, Lidia
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Wendel, Lotus
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Tridello, Gloria
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Knelange, Nina
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de la Camara, Ra ...
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Lortholary, Oliv ...
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Fontanet, Arnaud
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Styczynski, Jan
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Maertens, Johan
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Coussement, Juli ...
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Lebeaux, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Infec ...
- By the university
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Uppsala University