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An observational an...
An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring
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- Zaigham, Suneela (author)
- Uppsala University,Lunds universitet,Uppsala universitet,Klinisk fysiologi,Lund University, Malmö; Uppsala University, Uppsala,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Bertelsen, R J (author)
- University of Bergen, Bergen, Norway NO,Tartu University Clinics - Tartu, Estonia, EE,Tartu University Hospital
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- Dharmage, S C (author)
- The University of Melbourne, Melbourne, Australia AU,University of Bergen - Bergen, Norway, NO
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- Schlünssen, V (author)
- Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark, DK
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- Jögi, N O (author)
- Haukeland University Hospital, Bergen, Norway, NO
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- Gomez, L Palacios (author)
- Huelva, Andalusian Health Service - Huelva, Spain, ES
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- Holm, M (author)
- University of Gothenburg
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- Oudin, A. (author)
- Umeå University
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- Abramson, M J (author)
- Uppsala University
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- Sigsgaard, T (author)
- Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark, DK
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Jõgi, R (author)
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Svanes, C (author)
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- Olin, A C (author)
- University of Gothenburg
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- Forsberg, B (author)
- Umeå University
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- Janson, Christer (author)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning,Uppsala university, Uppsala
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- Nerpin, Elisabet, 1962- (author)
- Uppsala University,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Uppsala university, Uppsala
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Johannessen, A (author)
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Nitric oxide. - : Elsevier. - 1089-8603 .- 1089-8611. ; 149, s. 60-66
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Abstract
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- BACKGROUND: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring.METHODS: We studied 609 offspring aged 16-47 years from the Respiratory Health in Northern Europe, Spain and Australia generation (RHINESSA) study with parental information from the Respiratory Health in Northern Europe (RHINE) III study and the European Community Respiratory Health Survey (ECRHS) III. Linear regression models were used to assess the association between offspring FeNO and parental FeNO, allergic rhinitis, asthma and smoking, while adjusting for potential confounding factors.RESULTS: Parental allergic rhinitis was significantly associated with higher FeNO in the offspring, both on the paternal and maternal side (percent change: 20.3 % [95%CI 5.0-37.7], p = 0.008, and 13.8 % [0.4-28.9], p = 0.043, respectively). Parental allergic rhinitis with asthma in any parent was also significantly associated with higher offspring FeNO (16.2 % [0.9-33.9], p = 0.037). However, parental asthma alone and smoking were not associated with offspring FeNO. Parental FeNO was not associated with offspring FeNO after full adjustments for offspring and parental factors.CONCLUSIONS: Parental allergic rhinitis but not parental asthma was associated with higher levels of FeNO in offspring. These findings suggest that parental allergic rhinitis status should be considered when interpreting FeNO levels in offspring beyond childhood.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Allergic rhinitis
- Asthma
- FeNO
- Offspring
- Parental allergic disease
- Lungmedicin
- Lung Medicine
- Clinical Physiology
- Klinisk fysiologi
- Allergic rhinitis
- Asthma
- FeNO
- Offspring
- Parental allergic disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zaigham, Suneela
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Bertelsen, R J
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Dharmage, S C
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Schlünssen, V
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Jögi, N O
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Gomez, L Palacio ...
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show more...
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Holm, M
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Oudin, A.
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Abramson, M J
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Sigsgaard, T
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Jõgi, R
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Svanes, C
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Olin, A C
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Forsberg, B
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Janson, Christer
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Nerpin, Elisabet ...
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Johannessen, A
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Malinovschi, And ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Nitric oxide
- By the university
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Uppsala University
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Högskolan Dalarna
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Lund University