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Major cardiovascula...
Major cardiovascular events and death in parents of children with type 1 diabetes : a register-based matched cohort study in Sweden.
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- Kennedy, Beatrice, 1982- (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Wernroth, Mona-Lisa (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Batra, Gorav (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Hammar, Ulf (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Linroth, Cecilia (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Grönberg, Annika, MD, 1970- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Byberg, Liisa (author)
- Uppsala universitet,Medicinsk epidemiologi
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- Fall, Tove, 1979- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Diabetologia. - 0012-186X .- 1432-0428.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AIMS/HYPOTHESIS: Parenting a child with type 1 diabetes has been associated with stress-related symptoms. This study aimed to elucidate the potential impact on parental risk of major cardiovascular events (MCE) and death.METHODS: In this register-based study, we included the parents of 18,871 children, born 1987-2020 and diagnosed with type 1 diabetes in Sweden at <18 years. The median parental age at the child's diagnosis was 39.0 and 41.0 years for mothers and fathers, respectively. The cohort also encompassed 714,970 population-based matched parental control participants and 12,497 parental siblings. Cox proportional hazard regression models were employed to investigate the associations between having a child with type 1 diabetes and incident MCE and all-cause death, and, as secondary outcomes, acute coronary syndrome and ischaemic heart disease (IHD). We adjusted for potential confounders including parental type 1 diabetes and country of birth.RESULTS: During follow-up (median 12 years, range 0-35), we detected no associations between parenting a child with type 1 diabetes and MCE in mothers (adjusted HR [aHR] 1.02; 95% CI 0.90, 1.15) or in fathers (aHR 1.01; 95% CI 0.94, 1.08). We noted an increased hazard of IHD in exposed mothers (aHR 1.21; 95% CI 1.05, 1.41) with no corresponding signal in fathers (aHR 0.97; 95% CI 0.89, 1.05). Parental sibling analysis did not confirm the association in exposed mothers (aHR 1.01; 95% CI 0.73, 1.41). We further observed a slightly increased hazard of all-cause death in exposed fathers (aHR 1.09; 95% CI 1.01, 1.18), with a similar but non-significant estimate noted in exposed mothers (aHR 1.07; 95% CI 0.96, 1.20). The estimates from the sibling analyses of all-cause death in fathers and mothers were 1.12 (95% CI 0.90, 1.38) and 0.73 (95% CI 0.55, 0.96), respectively.CONCLUSIONS/INTERPRETATION: Having a child diagnosed with type 1 diabetes in Sweden was not associated with MCE, but possibly with all-cause mortality. Further studies are needed to disentangle potential underlying mechanisms, and to investigate parental health outcomes across the full lifespan.
Keyword
- Children
- Cohort study
- Death
- Epidemiology
- Ischaemic heart disease
- Major cardiovascular events
- Parents
- Sweden
- Type 1 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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