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Lineage specificati...
Lineage specification in glioblastoma is regulated by METTL7B
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- Constantinou, Myrianni (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Nicholson, James (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Zhang, Xinyu (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Maniati, Eleni (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Barts Canc Inst, London EC1M 6AS, England.
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- Lucchini, Sara (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Rosser, Gabriel (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Vinel, Claire (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Wang, Jun (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, Barts Canc Inst, London EC1M 6AS, England.
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- Lim, Yau Mun (author)
- UCL, Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.;UCL, Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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- Brandner, Sebastian (author)
- UCL, Univ Coll London Hosp NHS Fdn Trust, Natl Hosp Neurol & Neurosurg, Div Neuropathol, Queen Sq, London, England.;UCL, Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England.
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- Nelander, Sven (author)
- Uppsala universitet,Neuroonkologi och neurodegeneration
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- Badodi, Sara (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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- Marino, Silvia (author)
- Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England.
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Queen Mary Univ London, Blizard Inst, Brain Tumour Res Ctr, Barts & London Sch Med & Dent, London, England Queen Mary Univ London, Barts & London Sch Med & Dent, Barts Canc Inst, London EC1M 6AS, England. (creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Cell Reports. - : Elsevier. - 2211-1247. ; 43:6
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineage specification in glioblastoma, with an impact on both tumor size and invasiveness. Single-cell transcriptomic analysis of these tumors and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B reveal a regulatory role for the gene in the neural stem cell-to-astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via post-translational modifications of histone marks.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Constantinou, My ...
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Nicholson, James
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Zhang, Xinyu
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Maniati, Eleni
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Lucchini, Sara
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Rosser, Gabriel
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show more...
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Vinel, Claire
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Wang, Jun
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Lim, Yau Mun
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Brandner, Sebast ...
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Nelander, Sven
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Badodi, Sara
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Marino, Silvia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University