Search: onr:"swepub:oai:DiVA.org:uu-534535" >
Management of phaeo...
-
Taïeb, DavidAix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.
(author)
Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants : an international expert Consensus statement
- Article/chapterEnglish2024
Publisher, publication year, extent ...
-
Springer Nature,2024
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-534535
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-534535URI
-
https://doi.org/10.1038/s41574-023-00926-0DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:for swepub-publicationtype
Notes
-
Adult and paediatric patients with pathogenic variants in the gene encoding succinate dehydrogenase (SDH) subunit B (SDHB) often have locally aggressive, recurrent or metastatic phaeochromocytomas and paragangliomas (PPGLs). Furthermore, SDHB PPGLs have the highest rates of disease-specific morbidity and mortality compared with other hereditary PPGLs. PPGLs with SDHB pathogenic variants are often less differentiated and do not produce substantial amounts of catecholamines (in some patients, they produce only dopamine) compared with other hereditary subtypes, which enables these tumours to grow subclinically for a long time. In addition, SDHB pathogenic variants support tumour growth through high levels of the oncometabolite succinate and other mechanisms related to cancer initiation and progression. As a result, pseudohypoxia and upregulation of genes related to the hypoxia signalling pathway occur, promoting the growth, migration, invasiveness and metastasis of cancer cells. These factors, along with a high rate of metastasis, support early surgical intervention and total resection of PPGLs, regardless of the tumour size. The treatment of metastases is challenging and relies on either local or systemic therapies, or sometimes both. This Consensus statement should help guide clinicians in the diagnosis and management of patients with SDHB PPGLs.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Nölting, SvenjaUniv Zurich UZH, Univ Hosp Zurich USZ, Dept Endocrinol Diabetol & Clin Nutr, Zurich, Switzerland.;Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Dept Neurosurg, Munich, Germany.
(author)
-
Perrier, Nancy D.MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX USA.
(author)
-
Fassnacht, MartinUniv Wurzburg, Univ Hosp Wurzburg, Div Endocrinol & Diabet, Dept Med, Wurzburg, Germany.
(author)
-
Carrasquillo, Jorge A.Mem Sloan Kettering Canc Ctr, Dept Radiol, Mol Imaging & Therapy Serv, New York, NY 10065 USA.
(author)
-
Grossman, Ashley B.Univ Oxford, Green Templeton Coll, Oxford, England.;Royal Free Hosp, NET Unit, London, England.
(author)
-
Clifton-Bligh, RoderickUniv Sydney, Royal North Shore Hosp, Kolling Inst Med Res, Canc Genet Lab, Sydney, NSW, Australia.
(author)
-
Wanna, George B.Icahn Sch Med Mt Sinai, Dept Otolaryngol Head & Neck Surg, New York, NY USA.
(author)
-
Schwam, Zachary G.Icahn Sch Med Mt Sinai, Dept Otolaryngol Head & Neck Surg, New York, NY USA.
(author)
-
Amar, LaurenceUniv Paris, Equipe Labellisee Ligue Canc, INSERM, PARCC, Paris, France.;Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Hypertens Unit, Paris, France.
(author)
-
Bourdeau, IsabelleCtr hospitalier Univ Montreal CHUM, Dept Med, Res Ctr, Montreal, PQ, Canada.
(author)
-
Casey, Ruth T.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, Cambridgeshire, England.
(author)
-
Crona, JoakimUppsala universitet,Endokrin tumörbiologi(Swepub:uu)joacr310
(author)
-
Deal, Cheri L.Univ Montreal, Dept Paediat & Biochem, CHU Sainte Justine Res Ctr, Montreal, PQ H2L 4MI, Canada.
(author)
-
Del Rivero, JaydiraNCI, NIH, Ctr Canc Res, Dev Therapeut Branch, Bethesda, MD 20892 USA.
(author)
-
Duh, Quan-YangUCSF, Med Ctr Mt Z, San Francisco, CA USA.
(author)
-
Eisenhofer, GraemeTech Univ TU Dresden, Univ Hosp Carl Gustav Carus, Inst Clin Chem & Lab Med, Fetscherstr 74, D-01307 Dresden, Germany.
(author)
-
Fojo, TitoColumbia Univ, Irving Med Ctr, New York, NY USA.;James J Peters VA Med Ctr, New York, NY USA.
(author)
-
Ghayee, Hans K.Univ Florida, Dept Med, Div Endocrinol & Metab, Gainesville, FL 32610 USA.;Malcom Randall VA Med Ctr, Gainesville, FL USA.
(author)
-
Gimenez-Roqueplo, Anne-PauleUniv Paris, Equipe Labellisee Ligue Canc, INSERM, PARCC, Paris, France.;Hop Europeen Georges Pompidou, AP HP, Dept Vasc Med, F-75015 Paris, France.
(author)
-
Gill, Antony J.Univ Sydney, Royal N Shore Hosp, Dept Med Oncol, Sydney, NSW, Australia.;Royal North Shore Hosp, NSW Hlth Pathol, Dept Anat Pathol, St Leonards, NSW, Australia.
(author)
-
Hicks, RodneySt Vincents Hosp, Dept Med, Melbourne, Vic, Australia.
(author)
-
Imperiale, AlessioUniv Strasbourg, Inst Cancerol Strasbourg Europe ICANS, IPHC CNRS UMR 7178, Dept Nucl Med & Mol Imaging, Strasbourg, France.
(author)
-
Jha, AbhishekNatl Inst Child Hlth & Human Dev NICHD, NIH, Eunice Kennedy Shriver, Bethesda, MD USA.
(author)
-
Kerstens, Michiel N.Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
(author)
-
de Krijger, Ronald R.Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands.;Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands.
(author)
-
Lacroix, AndréUniv Montreal, Ctr Hospitalier Univ Montreal CRCHUM, Ctr Rech, Montreal, PQ, Canada.
(author)
-
Lazurova, IvicaPJ Safarik Univ Kosice, Dept Internal Med 2, Trieda SNP 1, Kosice 04011, Slovakia.
(author)
-
Lin, Frank I.NCI, NIH, Mol Imaging Program, Bethesda, MD 20892 USA.
(author)
-
Lussey-Lepoutre, CharlotteUniv Paris, Equipe Labellisee Ligue Canc, INSERM, PARCC, Paris, France.;Sorbonne Univ, Pitie Salpetriere Hosp, Dept Nucl Med, Paris, France.
(author)
-
Maher, Eamonn R.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, Cambridgeshire, England.
(author)
-
Mete, OzgurUniv Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
(author)
-
Naruse, MitsuhideNatl Hosp Org, Kyoto Med Ctr, Clin Res Inst, Ctr Endocrinol & Metab Dis, Kyoto, Japan.;Ijinkai Takeda Gen Hosp, Clin Res Ctr, Kyoto, Japan.
(author)
-
Nilubol, NarisNCI, NIH, Surg Oncol Program, Bethesda, MD 20892 USA.
(author)
-
Robledo, MercedesSpanish Natl Canc Res Ctr CNIO, Hereditary Endocrine Canc Grp, Madrid, Spain.;Univ Carlos III Madrid, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Dept Bioengn, Madrid, Spain.
(author)
-
Sebag, FrédéricAix Marseille Univ, Concept Hosp, Dept Endocrine Surg, Marseille, France.
(author)
-
Shah, Nalini S.Seth GS Med Coll & KEM Hosp, Dept Endocrinol, Mumbai, Maharashtra, India.
(author)
-
Tanabe, AkiyoNatl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, Tokyo, Japan.
(author)
-
Thompson, Geoffrey B.Mayo Clin, Dept Surg, Div Endocrine & Metab Surg, Rochester, MN USA.
(author)
-
Timmers, Henri J. L. M.Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands.
(author)
-
Widimsky, JiriCharles Univ Prague, Gen Univ Hosp, Fac Med 1, Dept Endocrinol & Metab,Dept Med 3, Prague 12808 2, Czech Republic.
(author)
-
Young, William J.Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN USA.
(author)
-
Meuter, LeahStanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA USA.
(author)
-
Lenders, Jacques W. M.Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands.
(author)
-
Pacak, KarelNatl Inst Child Hlth & Human Dev NICHD, NIH, Eunice Kennedy Shriver, Bethesda, MD USA.
(author)
-
Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.Univ Zurich UZH, Univ Hosp Zurich USZ, Dept Endocrinol Diabetol & Clin Nutr, Zurich, Switzerland.;Ludwig Maximilians Univ Munchen, Univ Hosp Munich, Dept Neurosurg, Munich, Germany.
(creator_code:org_t)
Related titles
-
In:Nature Reviews Endocrinology: Springer Nature20:3, s. 168-1841759-50291759-5037
Internet link
Find in a library
To the university's database
- By the author/editor
-
Taïeb, David
-
Nölting, Svenja
-
Perrier, Nancy D ...
-
Fassnacht, Marti ...
-
Carrasquillo, Jo ...
-
Grossman, Ashley ...
-
show more...
-
Clifton-Bligh, R ...
-
Wanna, George B.
-
Schwam, Zachary ...
-
Amar, Laurence
-
Bourdeau, Isabel ...
-
Casey, Ruth T.
-
Crona, Joakim
-
Deal, Cheri L.
-
Del Rivero, Jayd ...
-
Duh, Quan-Yang
-
Eisenhofer, Grae ...
-
Fojo, Tito
-
Ghayee, Hans K.
-
Gimenez-Roqueplo ...
-
Gill, Antony J.
-
Hicks, Rodney
-
Imperiale, Aless ...
-
Jha, Abhishek
-
Kerstens, Michie ...
-
de Krijger, Rona ...
-
Lacroix, André
-
Lazurova, Ivica
-
Lin, Frank I.
-
Lussey-Lepoutre, ...
-
Maher, Eamonn R.
-
Mete, Ozgur
-
Naruse, Mitsuhid ...
-
Nilubol, Naris
-
Robledo, Mercede ...
-
Sebag, Frédéric
-
Shah, Nalini S.
-
Tanabe, Akiyo
-
Thompson, Geoffr ...
-
Timmers, Henri J ...
-
Widimsky, Jiri
-
Young, William J ...
-
Meuter, Leah
-
Lenders, Jacques ...
-
Pacak, Karel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Nature Reviews E ...
- By the university
-
Uppsala University