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Hypocapnia in women...
Hypocapnia in women with fibromyalgia
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- Jonsson, Kent (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Centrum för klinisk forskning i Sörmland (CKFD),Nyköping Hosp, Dept Rehabil Med, Nyköping, Sweden.
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- Pikwer, Andreas (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Eskilstuna Cty Hosp, Dept Anesthesia, Eskilstuna, Sweden.
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- Olsson, Erik, 1967- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Peterson, Magnus, 1966- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin,Reg Uppsala, Acad Primary Hlth Care, Uppsala, Sweden.
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(creator_code:org_t)
- Walter de Gruyter, 2024
- 2024
- English.
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In: Scandinavian Journal of Pain. - : Walter de Gruyter. - 1877-8860 .- 1877-8879. ; 24:1
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Objectives: The purpose of this study was to investigate whether people with fibromyalgia (FM) have dysfunctional breathing by examining acid-base balance and comparing it with healthy controls.Methods: Thirty-six women diagnosed with FM and 36 healthy controls matched for age and gender participated in this cross-sectional study. To evaluate acid-base balance, arterial blood was sampled from the radial artery. Carbon dioxide, oxygen, bicarbonate, base excess, pH and lactate were analysed for between-group differences. Blood gas analyses were performed stepwise on each individual to detect acid-base disturbance, which was categorized as primary respiratory and possible compensation indicating chronicity. A three-step approach was employed to evaluate pH, carbon dioxide and bicarbonate in this order.Results: Women with FM had significantly lower carbon dioxide pressure (p = 0.013) and higher lactate (p = 0.038) compared to healthy controls at the group level. There were no significant differences in oxygen pressure, bicarbonate, pH and base excess. Employing a three-step acid-base analysis, 11 individuals in the FM group had a possible renally compensated mild chronic hyperventilation, compared to only 4 among the healthy controls (p = 0.042).Conclusions: In this study, we could identify a subgroup of individuals with FM who may be characterized as mild chronic hyperventilators. The results might point to a plausible dysfunctional breathing in some women with FM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- fibromyalgia
- acid
- base balance
- hypocapnia
- chronic hyperventilation
Publication and Content Type
- ref (subject category)
- art (subject category)
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