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Large-scale analysi...
Large-scale analysis of structural brain asymmetries during neurodevelopment : Associations with age and sex in 4265 children and adolescents.
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Kurth, F (author)
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Schijven, D (author)
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van den Heuvel, O A (author)
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show more...
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Hoogman, M (author)
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van Rooij, D (author)
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Stein, D J (author)
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Buitelaar, J K (author)
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Bölte, S (author)
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Auzias, G (author)
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Kushki, A (author)
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Venkatasubramanian, G (author)
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Rubia, K (author)
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Bollmann, S (author)
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- Isaksson, J (author)
- Uppsala universitet,Barn- och ungdomspsykiatri
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Jaspers-Fayer, F (author)
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Marsh, R (author)
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Batistuzzo, M C (author)
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Arnold, P D (author)
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Bressan, R A (author)
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Stewart, S E (author)
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Gruner, P (author)
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Sorensen, L (author)
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Pan, P M (author)
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Silk, T J (author)
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Gur, R C (author)
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Cubillo, A I (author)
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Haavik, J (author)
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O'Gorman Tuura, R L (author)
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Hartman, C A (author)
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Calvo, R (author)
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McGrath, J (author)
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Calderoni, S (author)
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Jackowski, A (author)
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Chantiluke, K C (author)
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Satterthwaite, T D (author)
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Busatto, G F (author)
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Nigg, J T (author)
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Gur, R E (author)
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Retico, A (author)
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Tosetti, M (author)
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Gallagher, L (author)
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Szeszko, P R (author)
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Neufeld, J (author)
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Ortiz, A E (author)
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Ghisleni, C (author)
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Lazaro, L (author)
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Hoekstra, P J (author)
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Anagnostou, E (author)
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Hoekstra, L (author)
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Simpson, B (author)
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Plessen, J K (author)
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Deruelle, C (author)
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Soreni, N (author)
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James, A (author)
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Narayanaswamy, J (author)
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Reddy, J Y (author)
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Fitzgerald, J (author)
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Bellgrove, M A (author)
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Salum, G A (author)
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Janssen, J (author)
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Muratori, F (author)
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Vila, M (author)
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Giral, M Garcia (author)
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Ameis, S H (author)
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Bosco, P (author)
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Remnélius, K Lundin (author)
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Huyser, C (author)
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Pariente, J C (author)
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Jalbrzikowski, M (author)
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Rosa, P G (author)
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O'Hearn, K M (author)
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Ehrlich, S (author)
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Mollon, J (author)
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Zugman, A (author)
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Christakou, A (author)
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Arango, C (author)
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Fisher, S E (author)
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Kong, X (author)
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Franke, B (author)
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Medland, S E (author)
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Thomopoulos, S I (author)
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Jahanshad, N (author)
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Glahn, D C (author)
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Thompson, P M (author)
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Francks, C (author)
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Luders, E (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Human Brain Mapping. - 1065-9471 .- 1097-0193. ; 45:11, s. e26754-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- ENIGMA
- adolescence
- age
- asymmetry
- brain
- childhood
- cortical thickness
- development
- gender
- gray matter
- sex
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Kurth, F
-
Schijven, D
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van den Heuvel, ...
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Hoogman, M
-
van Rooij, D
-
Stein, D J
-
show more...
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Buitelaar, J K
-
Bölte, S
-
Auzias, G
-
Kushki, A
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Venkatasubramani ...
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Rubia, K
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Bollmann, S
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Isaksson, J
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Jaspers-Fayer, F
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Marsh, R
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Batistuzzo, M C
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Arnold, P D
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Bressan, R A
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Stewart, S E
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Gruner, P
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Sorensen, L
-
Pan, P M
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Silk, T J
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Gur, R C
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Cubillo, A I
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Haavik, J
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O'Gorman Tuura, ...
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Hartman, C A
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Calvo, R
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McGrath, J
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Calderoni, S
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Jackowski, A
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Chantiluke, K C
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Satterthwaite, T ...
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Busatto, G F
-
Nigg, J T
-
Gur, R E
-
Retico, A
-
Tosetti, M
-
Gallagher, L
-
Szeszko, P R
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Neufeld, J
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Ortiz, A E
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Ghisleni, C
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Lazaro, L
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Hoekstra, P J
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Anagnostou, E
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Hoekstra, L
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Simpson, B
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Plessen, J K
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Deruelle, C
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Soreni, N
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James, A
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Narayanaswamy, J
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Reddy, J Y
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Fitzgerald, J
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Bellgrove, M A
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Salum, G A
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Janssen, J
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Muratori, F
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Vila, M
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Giral, M Garcia
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Ameis, S H
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Bosco, P
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Remnélius, K Lun ...
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Huyser, C
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Pariente, J C
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Jalbrzikowski, M
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Rosa, P G
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O'Hearn, K M
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Ehrlich, S
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Mollon, J
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Zugman, A
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Christakou, A
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Arango, C
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Fisher, S E
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Kong, X
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Franke, B
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Medland, S E
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Thomopoulos, S I
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Jahanshad, N
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Glahn, D C
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Thompson, P M
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Francks, C
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Luders, E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Human Brain Mapp ...
- By the university
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Uppsala University