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Epstein-Barr virus and cytomegalovirus in relation to testicular-cancer risk : a nested case-control study
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- Akre, Olof (author)
- Karolinska Institutet
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- Lipworth, Loren (author)
- Karolinska Institutet
- Tretli, Steinar (author)
- show more...
- Linde, Annika (author)
- Engstrand, Lars (author)
- Melbye, Mads (author)
- Ekbom, Anders (author)
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- (creator_code:org_t)
- 1999
- 1999
- English.
- In: International Journal of Cancer. - 0020-7136 .- 1097-0215. ; 82:1, s. 1-5
- Journal article (peer-reviewed)
Abstract
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- An infectious etiology of testicular cancer has been suggested. We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to testicular-cancer risk in a case-control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals. For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort. Serum IgG antibody titers against CMV and EBV were determined using enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence methods. Odds ratios (OR) were obtained from conditional logistic-regression models. No association was found between CMV positivity and testicular cancer overall (OR = 1.08; 95% confidence interval 0.60-1.94); risk for testicular seminoma was increased among CMV seropositive [OR = 1.70 (0.80-3.59)], whereas seropositivity was associated with decreased risk for testicular non-seminoma [OR = 0.54 (0.19-1.56)] (p for heterogeneity, 0.09). For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR = 2.74 (0.62-12.12)]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection.
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- MEDICIN
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- Lipworth, Loren
- Tretli, Steinar
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- Adami, Hans-Olov
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- Melbye, Mads
- Andersen, Aaage
- Ekbom, Anders
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