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Epstein-Barr virus ...
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Akre, OlofKarolinska Institutet
(author)
Epstein-Barr virus and cytomegalovirus in relation to testicular-cancer risk : a nested case-control study
- Article/chapterEnglish1999
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-54230
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-54230URI
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https://doi.org/10.1002/(SICI)1097-0215(19990702)82:1<1::AID-IJC1>3.0.CO;2-LDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1947408URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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An infectious etiology of testicular cancer has been suggested. We have evaluated seroreactivity against cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in relation to testicular-cancer risk in a case-control study, nested within a cohort of prospectively collected serum specimens from 293,692 individuals. For each of 81 cases of testicular cancer identified, 3 controls were randomly selected from the cohort. Serum IgG antibody titers against CMV and EBV were determined using enzyme-linked immunosorbent assays (ELISAs) and immunofluorescence methods. Odds ratios (OR) were obtained from conditional logistic-regression models. No association was found between CMV positivity and testicular cancer overall (OR = 1.08; 95% confidence interval 0.60-1.94); risk for testicular seminoma was increased among CMV seropositive [OR = 1.70 (0.80-3.59)], whereas seropositivity was associated with decreased risk for testicular non-seminoma [OR = 0.54 (0.19-1.56)] (p for heterogeneity, 0.09). For EBV, the risk for testicular cancer was increased among individuals seropositive for viral capsid antigen (VCA) [OR = 2.74 (0.62-12.12)]. The results lend some support to the hypothesis of an infectious etiology, and we propose that future studies should take into account age at infection.
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Lipworth, LorenKarolinska Institutet
(author)
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Tretli, Steinar
(author)
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Linde, Annika
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Engstrand, Lars
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Adami, Hans-OlovKarolinska Institutet
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Melbye, Mads
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Andersen, AaageKarolinska Institutet
(author)
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Ekbom, Anders
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:International Journal of Cancer82:1, s. 1-50020-71361097-0215
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