SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-54486"
 

Search: onr:"swepub:oai:DiVA.org:uu-54486" > Positron emission t...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Positron emission tomography and radioimmunotargeting : general aspects

Lundqvist, Hans (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
Lubberink, Mark (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
Tolmachev, Vladimir (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
show more...
Lövqvist, Anna (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
Sundin, Anders (author)
Uppsala universitet,Enheten för radiologi,RAD
Beshara, Soheir (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Njurmedicinska gruppen
Bruskin, Alexander (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
Carlsson, Jörgen (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,BMS
Westlin, Jan-Erik (author)
Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Oncology
show less...
 (creator_code:org_t)
1999
1999
English.
In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 38:3, s. 335-341
Related links:
https://urn.kb.se/re...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To optimize radioimmunotherapy, in vivo information on individual patients, such as radionuclide uptake, kinetics, metabolic patterns and optimal administration methods, is important. An overriding problem is to determine accurately the absorbed dose in the target organ as well as critical organs. Positron Emission Tomography (PET) is a superior technique to quantify regional kinetics in vivo with a spatial resolution better than 1 cm3 and a temporal resolution better than 10 s. However, target molecules often have distribution times of several hours to days. Conventional PET nuclides are not applicable and alternative positron-emitting nuclides with matching half-lives and with suitable labelling properties are thus necessary. Over many years we have systematically developed convenient production methods and labelling techniques of suitable positron nuclides, such as 110In(T(1/2) = 1.15 h), 86Y(T(1/2) = 14 h), 76Br(T(1/2) = 16 h) and 124I(T(1/2) = 4 days). 'Dose planning' can be done, for example, with 86Y- or 124I-labelled ligands before therapy, and 90Y- and 131I-labelled analogues and double-labelling, e.g. with a 86Y/90Y-labelled ligand, can be used to determine the true radioactivity integral from a pure beta-emitting nuclide. The usefulness of these techniques was demonstrated in animal and patient studies by halogen-labelled MAbs and EGF-dextran conjugates and peptides chelated with metal ions.

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view