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Suppression of the ...
Suppression of the neoplastic phenotype by transfection of phospholipase C3 to neuroendocrine tumor cells
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- Stålberg, Peter (author)
- Uppsala universitet,Medicin,Onkologisk endokrinologi, K Öberg
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- Wang, Shu (author)
- Uppsala universitet,Medicin,Onkologisk endokrinologi, K Öberg
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- Larsson, Catharina (author)
- Karolinska Institutet,Uppsala universitet,Molekylär medicin
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- Weber, Günther (author)
- Uppsala universitet,Molekylär medicin
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- Öberg, Kjell (author)
- Uppsala universitet,Medicin,Onkologisk endokrinologi, K Öberg
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- Gobl, Anders (author)
- Uppsala universitet,Medicin,Onkologisk endokrinologi, K Öberg
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- Skogseid, Britt (author)
- Uppsala universitet,Medicin,Onkologisk endokrinologi, K Öberg
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Weber, C (author)
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: FEBS Letters. - 0014-5793 .- 1873-3468. ; 450:3, s. 210-216
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The expression of phospholipase C beta 3 (PLCB3) is low or absent in several neuroendocrine neoplasias. To investigate the role of PLCB3 in the neuroendocrine tumorigenesis, we transfected a PLCB3 construct to three neuroendocrine tumor cell lines with a low PLCB3 expression. The growth rate and tumorigenicity were assessed in vitro by [3H]thymidine incorporation and cell counting, in vivo, by xenografting to nude mice. In vitro, PLCB3 expressing clones showed a significant growth inhibition. The tumor weight was reduced for one of the two xenografted PLCB3-transfected cell lines and in both, a reduced number of proliferating (Ki-67 positive) cells was observed. This study implies an essential role for PLCB3 in the neuroendocrine tumorigenesis.
Publication and Content Type
- ref (subject category)
- art (subject category)
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