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Olsalazine versus s...
Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis : A multicenter study
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Nilsson, Å. (author)
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Danielsson, Å. (author)
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- Löfberg, R. (author)
- Karolinska Institutet
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Benno, P. (author)
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Bergman, L. (author)
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Fausa, O. (author)
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Florholmen, J. (author)
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Karvonen, A-L. (author)
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Kildebo, S. (author)
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Kollenber, B. (author)
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Lindberg, G. (author)
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- Lööf, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Gastroenterologigruppen, L Lööf
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Stig, R. (author)
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Tanghoj, H. (author)
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(creator_code:org_t)
- 1995
- 1995
- English.
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In: American Journal of Gastroenterology. - 0002-9270 .- 1572-0241. ; 90:3, s. 381-387
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Abstract
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- OBJECTIVE: To compare the relapse-preventing effect and the frequency of adverse events of olsalazine and sulphasalazine in sulphasalazine-tolerant patients with ulcerative colitis. METHODS: Patients in remission, with at least two episodes of active disease during the last 5 yr, were randomized to 2 g of sulphasalazine or 1 g of olsalazine daily and were followed for 6-18 months. Relapse rates in the two groups were compared using frequency and life-table analysis. Sixty-nine patients with proctitis, 140 with left-sided colitis, and 113 with subtotal or total colitis were evaluated. RESULTS: In the intention-to-treat analysis, the failure rate (relapses plus withdrawals) was 54.7% in the olsalazine and 47.2% in the sulphasalazine group. In the per-protocol analysis excluding withdrawals, 44.7% relapsed in the olsalazine and 39.3% in the sulphasalazine group. Remission curves did not differ significantly, although at all time intervals the frequency of remission was slightly higher in the sulphasalazine group (p = 0.19 in the intention-to-treat analysis and p = 0.42 in the per-protocol analysis estimated by the log-rank test). Twelve patients (of whom five had diarrhea) in the olsalazine group versus eight patients in the sulphasalazine group discontinued the study because of side effects. CONCLUSION: The relapse-preventing effect of olsalazine and sulphasalazine in sulphasalazine-tolerant patients did not differ. Furthermore, the tolerability of olsalazine, particularly concerning diarrhea, appears to be better than previously reported.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nilsson, Å.
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Danielsson, Å.
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Löfberg, R.
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Benno, P.
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Bergman, L.
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Fausa, O.
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show more...
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Florholmen, J.
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Karvonen, A-L.
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Kildebo, S.
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Kollenber, B.
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Lindberg, G.
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Lööf, Lars
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Stig, R.
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Tanghoj, H.
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show less...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet