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- Bill-Axelson, Anna,1965-Uppsala universitet,Institutionen för kirurgiska vetenskaper (author)
Localized Prostate Cancer : Results From a Randomized Clinical Trial
- BookEnglish2005
Publisher, publication year, extent ...
- Uppsala :Acta Universitatis Upsaliensis,2005
- 45 s.
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-5737
- ISBN:9155462065
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5737URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Varying forms of title
- Lokaliserad prostatacancer :Resultat från en randomiserad klinisk studie
Series
- Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;25
Notes
- The aims of the thesis were to• explore whether radical prostatectomy is beneficial compared with watchful waiting in survival and disease progression• find possible effect modifiers• evaluate a protocol of multiple biopsies and investigate if men with previous benign prostate biopsies are a group at risk for later prostate cancer• inquire into patients’ and clinicians’ experiences of randomization in order to find out what made this study possible to conduct, and thereby contribute to improve randomization in the futureThe background material was a large randomized clinical trial, the Scandinavian Prostatic Cancer Group Study Number 4, or SPCG-4, which was open for inclusion from February 1989 through December 1999. It comprised 695 men in Sweden, Finland and Iceland who had localized prostate cancer and were randomized to either radical prostatectomy or watchful waiting. After a mean follow-up time of 6.2 years the first analyses, according to intention-to-treat, showed that radical prostatectomy reduced disease specific mortality, risk of metastases and risk of local progression but did not statistically significantly reduce overall mortality. The second analyses confirmed our earlier findings and furthermore, at ten years, radical prostatectomy also statistically significantly reduced overall mortality. Age appeared as an independent effect modifier that will be further investigated.A total of 547 men, with a suspicion of prostate cancer that had undergone multiple biopsies, and whose biopsies had benign histology were later compared with the background population to evaluate whether they were a group at risk of developing prostate cancer. Within six years of follow-up, there was no increased risk of prostate cancer.Patients as well as clinicians used individual strategies to cope with the situation. The randomizing clinician has to understand the patient’s strategy and his expectations in order to individualize the information accordingly.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- Surgery
- prostate cancer
- localized
- randomized
- biopsies
- interviews
- Kirurgi
- Surgery
- Kirurgi
Added entries (persons, corporate bodies, meetings, titles ...)
- Holmberg, Lars (thesis advisor)
- Norlén, Bo Johan (thesis advisor)
- Wiklund, Peter,professorInstitutionen för kirurgisk vetenskap sektionen för urologi, Stockholm (opponent)
- Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)
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