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Elevated serum leve...
Elevated serum levels of soluble ICAM-1 are elevated in non-Hodgkin´s lymphomas and correlate with tumor burden, disease activity and other diagnostic markers
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- Christiansen, Ilse (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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- Gidlöf, Cecilia (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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Kälkner, Karl-Mikael (author)
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Hagberg, H. (author)
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Bennmarker, H. (author)
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- Tötterman, Thomas H. (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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(creator_code:org_t)
- 1996
- 1996
- English.
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In: British Journal of Haematology. - 0007-1048 .- 1365-2141. ; 92:3, s. 639-46
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- The serum levels of soluble ICAM-1 (CD54) were significantly elevated in patients with non-Hodgkin's lymphomas (NHL, n=127) and hairy cell leukaemia (HCL, n=15) compared with healthy controls (n=31). In high-grade malignant NHL (n=79) the sICAM-1 levels correlated with the tumour mass as reflected in the Ann Arbor staging system but not with bulky disease. Further, the sICAM-1 levels correlated with disease activity as reflected by the presence of B symptoms and with other known prognostic markers. In particular serum thymidine kinase (sTK). In patients with low-grade malignant NHL (n=48) a trend towards higher serum levels of sICAM-1 was found in patients with advanced stage and B symptoms. In both low and high-grade malignant NHL, elevated levels of sICAM-1 were associated with poorer overall and disease-free survival. The present results indicated that sICAM-1 levels have a prognostic power equal to that of other serum markers claimed to be of prognostic value in NHL, namely serum lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), beta-2-microglobulin (beta2m), serum thymidine kinase (sTK), albumin and orosomucoid. The cellular origin and the possible interactions between soluble and surface ICAM-1 and its ligands needs further exploration.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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