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Elevated serum leve...
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Christiansen, IlseUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
(author)
Elevated serum levels of soluble ICAM-1 are elevated in non-Hodgkin´s lymphomas and correlate with tumor burden, disease activity and other diagnostic markers
- Article/chapterEnglish1996
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LIBRIS-ID:oai:DiVA.org:uu-57516
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-57516URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The serum levels of soluble ICAM-1 (CD54) were significantly elevated in patients with non-Hodgkin's lymphomas (NHL, n=127) and hairy cell leukaemia (HCL, n=15) compared with healthy controls (n=31). In high-grade malignant NHL (n=79) the sICAM-1 levels correlated with the tumour mass as reflected in the Ann Arbor staging system but not with bulky disease. Further, the sICAM-1 levels correlated with disease activity as reflected by the presence of B symptoms and with other known prognostic markers. In particular serum thymidine kinase (sTK). In patients with low-grade malignant NHL (n=48) a trend towards higher serum levels of sICAM-1 was found in patients with advanced stage and B symptoms. In both low and high-grade malignant NHL, elevated levels of sICAM-1 were associated with poorer overall and disease-free survival. The present results indicated that sICAM-1 levels have a prognostic power equal to that of other serum markers claimed to be of prognostic value in NHL, namely serum lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), beta-2-microglobulin (beta2m), serum thymidine kinase (sTK), albumin and orosomucoid. The cellular origin and the possible interactions between soluble and surface ICAM-1 and its ligands needs further exploration.
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Gidlöf, CeciliaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM
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Kälkner, Karl-Mikael
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Hagberg, H.
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Bennmarker, H.
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Tötterman, Thomas H.Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM(Swepub:uu)thomtott
(author)
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Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Related titles
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In:British Journal of Haematology92:3, s. 639-460007-10481365-2141
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