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Cognitive decline i...
Cognitive decline in patients with symptomtic HIV-1 infection : No decline in asymptomatic infection
- Article/chapterEnglish1996
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LIBRIS-ID:oai:DiVA.org:uu-57593
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-57593URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.
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Elovaara, I.
(author)
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Raininko, RailiUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,RAD
(author)
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Vilkki, J.
(author)
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Lähdevirta, J.
(author)
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Iivanainen, M.
(author)
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Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi
(creator_code:org_t)
Related titles
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In:Acta Neurologica Scandinavica93:6, s. 421-70001-63141600-0404
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