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Cloning and sequenc...
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Hjälm, GöranUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
(author)
Cloning and sequencing of human gp330, a Ca2+ -binding receptor with potential intracellular signaling properties
- Article/chapterEnglish1996
Publisher, publication year, extent ...
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Wiley,1996
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-58189
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-58189URI
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https://doi.org/10.1111/j.1432-1033.1996.0132u.xDOI
Supplementary language notes
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Language:English
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Summary in:English &language:-1_t
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats. The deduced 4655 amino acid residues give a calculated molecular mass of 519636 Da for the mature protein and consists of a probable 25-amino-acid N-terminal signal peptide sequence, an extracellular region of 4398 amino acids, a single transmembrane-spanning domain of 23 amino acids, and an intracellular C-terminal region of 209 amino acid residues. Three types of cysteine-rich repeats characteristic of the low density lipoprotein receptor (LDLR) superfamily are present in human gp330. In the extracellular region, there are a total of 36 LDLR ligand-binding repeats, comprising four distinct domains, 16 growth factor repeats separated by eight YWTD spacer regions, and one epidermal growth factor-like repeat. No consensus cleavage sequence for the processing endoprotease furin is detected in human gp330. The intracellular tail contains not only two copies of the F(X)NPXY coated-pit mediated internalization signal characteristic of LDLR superfamily members, but also intriguing and potentially functional motifs including several Src-homology 3 recognition motifs, one Src-homology 2 recognition motif for the p85 regulatory subunit of phosphatidylinositol 3-kinase, and additional sites for protein kinase C, casein kinase II and cAMP-/cGMP-dependent protein kinase. There is approximately 77% amino acid identity between human and rat gp330 with minor differences between the extracellular and intracellular regions. Recently gp330 has been implicated in Ca2+ regulation in the parathyroid, the placenta, and the renal tubule, but its overall physiological and pathological role still remains uncertain.
Subject headings and genre
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Heymann nephritis
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calcium signaling
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cysteine repeats
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low-density-lipoprotein-receptor superfamily
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endocytic receptor
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MEDICINE
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MEDICIN
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NATURAL SCIENCES
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NATURVETENSKAP
Added entries (persons, corporate bodies, meetings, titles ...)
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Murray, Edward
(author)
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Crumley, Gregg
(author)
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Harazim, William
(author)
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Lundgren, Stefan
(author)
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Onyango, Isaac
(author)
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Ek, Bo
(author)
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Larsson, Mårten
(author)
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Juhlin, ClaesUppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
(author)
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Hellman, PerUppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
(author)
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Davis, Hughes
(author)
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Åkerström, GöranUppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
(author)
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Rask, LarsUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
(author)
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Morse, Buzzy
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:European Journal of Biochemistry: Wiley239:1, s. 132-1370014-29561432-1033
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- By the author/editor
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Hjälm, Göran
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Murray, Edward
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Crumley, Gregg
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Harazim, William
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Lundgren, Stefan
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Onyango, Isaac
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Ek, Bo
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Larsson, Mårten
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Juhlin, Claes
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Hellman, Per
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Davis, Hughes
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Åkerström, Göran
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Rask, Lars
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Morse, Buzzy
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Uppsala University