Intestinal mucosal injury during porcine faecal peritonitis

Wollert, StaffanUppsala universitet,Institutionen för kirurgiska vetenskaper (author)

OBJECTIVE: To assess the incidence of intestinal mucosal injury during faecal peritonitis in pigs, the relation of such lesions to haemodynamic variables, intramucosal pH (pHi), and endothelial adherence of polymorphonuclear leucocytes (PMNs). DESIGN: Experimental laboratory study. SETTING: University department of surgery, Sweden. SUBJECTS: 57 Juvenile pigs. INTERVENTIONS: Pigs had faecal peritonitis induced (n = 39) or a sham procedure (n = 18). In addition, 15 animals were pretreated with the monoclonal CD18 receptor antibody IB4 before induction of peritonitis with the aim of preventing tissue accumulation of PMNs. MAIN OUTCOME MEASURES: Development of mucosal lesions and correlation with haemodynamic variables. RESULTS: 17/18 (94%) of control animals had normal mucosa. The incidence of mucosal lesions in animals with faecal peritonitis was 56%. Animals with severe mucosal injury (grade 4-5) had significantly lower mean arterial pressure, cardiac index, and pHi during the last hour of the experiment compared with animals without mucosal lesions. Pretreatment with IB4 did not prevent the development of intestinal mucosal injuries. Intramucosal pH decreased during sepsis and was not affected by IB4. CONCLUSIONS: Severe intestinal mucosal injury is associated with arterial hypotension, low cardiac index, and low pH. Neither the mucosal injury nor the reduction in pHi seen during porcine faecal peritonitis seemed to be leucocyte-related phenomena.

Antonsson, J.Uppsala universitet,Institutionen för kirurgiska vetenskaper (author)
Lundberg, C. (author)
Gerdin, BengtUppsala universitet,Plastikkirurgi,Plastic Surgery(Swepub:uu)bengtgd (author)
Rasmussen, Ib ChristianUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery(Swepub:uu)ibrasmus (author)
Haglund, UlfUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal Surgery (author)
Uppsala universitetInstitutionen för kirurgiska vetenskaper (creator_code:org_t)

By the author/editor: Wollert, Staffan; Antonsson, J.; Lundberg, C.; Gerdin, Bengt; Rasmussen, Ib Ch ...; Haglund, Ulf

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