Search: onr:"swepub:oai:DiVA.org:uu-59643" >
Inactivation of H19...
Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis
-
Cui, H (author)
-
- Hedborg, F (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Zoologisk utvecklingsbiologi,Barnonkologisk forskning/Lönnerholm
-
He, L (author)
-
show more...
-
Nordenskjold, A (author)
-
- Pfeifer, S (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Zoologisk utvecklingsbiologi,Barnonkologisk forskning/Lönnerholm
-
- Ohlsson, R (author)
- Karolinska Institutet,Uppsala universitet,Zoologisk utvecklingsbiologi
-
- Sandstedt, B (author)
- Karolinska Institutet
-
PfeiferOhlsson, S (author)
-
show less...
-
(creator_code:org_t)
- 1997
- 1997
- English.
-
In: Cancer Research. ; 57:20, s. 4469-4473
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Genetic evidence shows that the parent of origin-dependent expression patterns of the Igf2 and H19 genes is coordinated in mouse, such that H19 controls the activity of Igf2 in cis. Equally compelling evidence for a similar situation in humans is absent, although the frequently observed activation of the maternal IGF2 allele (ie., loss of imprinting) in Wilms' tumors has been attributed to the silencing of the maternal H19 locus. We show here that loss of H19 activity is generally a preneoplastic event, which may be linked with an overgrowth lesion that has been proposed to be permissive for tumor formation. Although our results document one instance in which a postneoplastic loss of H19 activity correlates with loss of IGF2 imprinting at the cellular level, it appears that inactivation of H19 is more generally independent of loss of imprinting of IGF2, at least in our specimens. Our results imply that inactivation of H19 correlates with blastema overgrowth and can be independent of a regulatory role with respect to IGF2 imprinting status in cis.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database