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Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Technique
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- Kristjánsson, Guðjón, 1962- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
- Hällgren, Roger (thesis advisor)
- Venge, Per (thesis advisor)
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- ISBN 9155463746
- Uppsala : Acta Universitatis Upsaliensis, 2005
- English 69 s.
- Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 80
- Doctoral thesis (other academic/artistic)
Abstract
Subject headings
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- A diagnosis of coeliac disease (CD) in adults relies on the presence of a structurally abnormal intestinal mucosa, followed by a clear clinical remission on a gluten-free diet. There is a clear need for a rapid, simple, safe and sensitive method to determine the type and intensity of inflammation in the gut mucosa in clinical practice. The overall aims of our studies were to develop and evaluate a new technique, “the mucosal patch technique”, to characterize rectal local inflammatory process after rectal food challenge in patients with CD. In study 1 we evaluated the potential of the new technique. The technique was well tolerated and easily applied. Pronounced neutrophil and eosinophil involvement in ulcerative colitis (UC) was demonstrated. With the high sensitivity of the technique, low-degree mucosal neutrophil activation could also be quantified in patients with collagen colitis,UC in clinical remission and in patients with irritable bowel syndrome. In study 2 and 3 the aim was to elucidate the dynamics of the rectal inflammatory response and nitric oxide (NO) production after rectal gluten challenge. We found a pronounced neutrophil activation in coeliac patients after rectal gluten challenge. This activation was apparent 4 hours after challenge and remains for at least 48 hours. A more modest eosinophil activation started 1-2 hours later and remained at least for 48 hours. The biphasic pattern of neutrophil and eosinonphil activation after challenge suggests a biphasic inflammatory reaction. The activation of neutrophils and eosinophils precedes a pronounced enhancement of mucosal NO production. Some of our coeliac patients displayed signs of an inflammatory reaction after rectal corn gluten challenge. In study 4 the aim was to investigate the local inflammatory reaction to gluten and cow’s milk protein in CD patients in remission. The findings indicate that not only gluten sensitivity but also cow’s milk (CM) protein sensitivity is common in CD. The data support the hypothesis that CM sensitivity may contribute to persistent symptoms in coeliac patients on gluten-free diet.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Medicine
- Coeliac disease
- Diagnostic instrument
- food hypersensitivity
- gut pathophysiologi
- inflammation
- nitric oxide
- rectal instillation
- gluten
- corn
- milk hypersensitivity
- inflammatory bowel disease
- irritable bowel syndrome
- Medicin
- Dermatology and venerology,clinical genetics, internal medicine
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Publication and Content Type
- vet (subject category)
- dok (subject category)
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