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Thrombin generation...
Thrombin generation during cardiopulmonary bypass using heparin-coated circuits or standard circuits
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- Ernofsson, Mats (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Coagulation Research
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- Thelin, Stefan (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Thoracic Surgery
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- Siegbahn, Agneta (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Coagulation Research
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(creator_code:org_t)
- 1995
- 1995
- English.
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In: Scandinavian journal of thoracic and cardiovascular surgery. - 0036-5580. ; 29:4, s. 157-165
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- For quantitative comparison of thrombin generation during cardiopulmonary bypass (CPB) with heparin-coated vs conventional CPB circuits, thrombin-antithrombin III complex (TAT) and prothrombin fragment 1 + 2 (F1 + 2) were analyzed in 20 patients undergoing combined heart valve surgery and coronary artery bypass grafting (CABG), in ten cases with heparin-coated circuits (COMB-HC) and in ten with standard circuits (COMB-C). Extensive thrombin generation was found in both groups, with maximal TAT and F1 + 2 levels at the end of CPB. Of 15 operations with only CABG, seven were performed with heparin-coated circuits and heparin dose 40% of normal (CABG-HC), and eight with standard circuits and normal heparin doses (CABG-C). TAT was maximal at the end of CPB and F1 + 2 peaked 3 hours after protamine injection. At the end of CPB both levels were significantly higher in the CABG-HC than in the CABG-C group, though thrombin generation was less than in the COMB groups. The abundant thrombin generation during CPB thus was much more pronounced during complex operations. Use of heparin-coated circuits did not reduce thrombin generation, which was increased by 60% reduction of the systemic heparin dose. The clinical implications are still unknown, as no complications were observed.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- vet (subject category)
- rec (subject category)
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