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Propofol (Diprivan-...
Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock
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- Basu, Samar (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Mutschler, Diana K. (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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- Larsson, Anders O. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical Chemistry
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- Kiiski, Ritva (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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- Nordgren, Anders (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
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- Eriksson, Mats (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Resuscitation. - 0300-9572 .- 1873-1570. ; 50:3, s. 341-348
- Related links:
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https://urn.kb.se/re...
Abstract
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- PURPOSE: Human septic shock can be replicated in the endotoxaemic pig. Endotoxaemia causes a multitude of events, including reduced PaO(2) and increased lipid peroxidation. This study was designed to evaluate the possible effects of a commonly used anaesthetic drug with known antioxidant properties (propofol) during porcine endotoxaemia.METHODS: Ten pigs were anaesthetised and given a 6 h E. coli endotoxin infusion. The animals received, randomly, a supplementary continuous infusion of propofol emulsion (containing 0.005% EDTA) or the corresponding volume of vehicle (controls). Pathophysiologic responses were determined. Non-enzymatic (by measuring plasma 8-iso-PGF(2 alpha) and enzymatic (by measuring plasma 15-keto-dihydro-PGF(2 alpha)) lipid peroxidations were evaluated. Plasma levels of the endogenous antioxidants alpha- and gamma-tocopherols, were also analysed.RESULTS: Endotoxaemia increased plasma levels of 8-iso-PGF(2 alpha) (1st-4th h) and 15-keto-dihydro-PGF(2 alpha) (1st-4th h) significantly more in controls than in the propofol+endotoxin group. PaO(2) was significantly less affected by endotoxin in the propofol treated animals (2nd-4th h). Mean arterial pressure (4th-6th h) and systemic vascular resistance (6th h) were reduced significantly more by endotoxin among the propofol-treated animals. Vitamin E (alpha-tocopherol) increased in all animals, significantly more in the propofol+endotoxin group (1/2-6th h) than in the control group.CONCLUSIONS: Propofol reduced endotoxin-induced free radical mediated and cyclooxygenase catalysed lipid peroxidation significantly. The implication is that propofol counteracts endotoxin-induced deterioration of PaO(2).
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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