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Isolation of high purity 1-[2′,4′-dihydroxy-3′,5′-di-(3″-methylbut-2″-enyl)-6′-methoxy] phenylethanone from Acronychia pedunculata (L.) Miq. by high-speed counter-current chromatography
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- Han, Xiao (author)
- Uppsala universitet,Institutionen för ytbioteknik med Centrum för ytbioteknik,Institutionen för fysikalisk och analytisk kemi
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- Pathmasiri, Wimal (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- Bohlin, Lars (author)
- Uppsala universitet,Avdelningen för farmakognosi
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- (creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
- In: Journal of Chromatography A. - : Elsevier BV. - 0021-9673 .- 1873-3778. ; 1022:1-2, s. 213-216
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Following an initial clean-up step on silica, high-speed counter-current chromatography (HSCCC) was used to purify an aryl ketone, 1-[2′,4′-dihydroxy-3′,5′-di-(3″-methylbut-2″-enyl)-6′-methoxy] phenylethanone from an extract of the stem bark of the shrub Acronychia pedunculata. The two-phase solvent system used was composed of n-heptane–ethyl acetate–methanol–water at an optimized volume ratio of 4:1:4:1 (v/v/v/v). Target compound (58.1 mg) with a purity of 98.9% was obtained after HSCCC of 183.5 mg sample with a purity of 35.7% recovered after the silica clean-up step. Identification of the target compound was performed by 1H NMR, 13C NMR, two-dimensional NMR and LC–electrospray ionization MS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Acronychia pedunculata
- Counter-current chromatography
- Pharmaceutical analysis
- Dihydroxydimethylbutenylmethoxyl phenylethanone
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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