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Molecular tools for...
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Landegren, UlfUppsala universitet,Institutionen för genetik och patologi
(author)
Molecular tools for a molecular medicine : analyzing genes, transcripts and proteins using padlock and proximity probes
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2004-05-05
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Wiley,2004
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-65440
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-65440URI
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https://doi.org/10.1002/jmr.664DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Procedures and reagents are needed to specifically detect all the macromolecules that are being identified in the course of genome projects. We discuss how this challenge may be met using a set of ligation-based reagents termed padlock probes and proximity ligation probes. These probes include elements with affinity for specific nucleic acid and protein molecules, respectively, along with unique identifier DNA sequence elements that encode the identity of the recognized target molecules. The information content of DNA strands that form in the detection reactions are recorded after amplification, allowing the recognized target molecules to be identified. The procedures permit highly specific solution-phase or localized analyses of large sets of target molecules as required in future molecular analyses.
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Schallmeiner, EdithUppsala universitet,Institutionen för genetik och patologi
(author)
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Nilsson, MatsUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)matsnils
(author)
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Fredriksson, SimonUppsala universitet,Institutionen för genetik och patologi
(author)
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Banér, JohanUppsala universitet,Institutionen för genetik och patologi
(author)
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Gullberg, MatsUppsala universitet,Institutionen för genetik och patologi
(author)
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Jarvius, JonasUppsala universitet,Institutionen för genetik och patologi
(author)
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Gustafsdottir, SigrunUppsala universitet,Institutionen för genetik och patologi
(author)
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Dahl, FredrikUppsala universitet,Institutionen för genetik och patologi
(author)
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Söderberg, OlaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)olasoder
(author)
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Ericsson, OlleUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)oleri021
(author)
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Stenberg, JohanUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)joste021
(author)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
Related titles
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In:Journal of Molecular Recognition: Wiley17:3, s. 194-70952-34991099-1352
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Landegren, Ulf
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Schallmeiner, Ed ...
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Nilsson, Mats
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Fredriksson, Sim ...
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Banér, Johan
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Gullberg, Mats
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Jarvius, Jonas
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Gustafsdottir, S ...
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Dahl, Fredrik
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Söderberg, Ola
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Ericsson, Olle
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Stenberg, Johan
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Uppsala University