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Normal weight promo...
Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
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- Schölin, Anna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Törn, Carina (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Nyström, Lennarth (author)
- Umeå universitet,Epidemiologi och folkhälsovetenskap
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- Berne, Christian (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Arnqvist, Hans, 1943- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för medicinsk cellbiologi,Endokrin- och magtarmmedicinska kliniken US
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Blohme, G (author)
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- Bolinder, J (author)
- Karolinska Institutet
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- Eriksson, Jan W (author)
- Umeå universitet,Medicin
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- Kockum, I (author)
- Karolinska Institutet
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- Landin-Olsson, Mona (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Östman, J (author)
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- Karlsson, F Anders (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Sundkvist, Göran (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Björk, Elisabeth (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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(creator_code:org_t)
- Wiley, 2004
- 2004
- English.
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In: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 21:5, s. 447-455
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Abstract
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- Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM).Methods In Sweden, 362 patients (15–34 years), classified as Type 1 DM were included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA1c and insulin dosage over a median period after diagnosis of 5 years. Duration of remission, defined as an insulin maintenance dose ≤ 0.3 U/kg/24 h and HbA1c within the normal range, was analysed in relation to characteristics at diagnosis.Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1–73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab+), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20–24.9 kg/m2) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab+ remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions.Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adolescent
- Adult
- Autoantibodies/*blood
- Body Mass Index
- Body Weight
- Diabetes Mellitus; Type 1/drug therapy/*immunology/pathology
- Drug Administration Schedule
- Female
- Humans
- Hypoglycemic Agents/administration & dosage
- Insulin/administration & dosage
- Islets of Langerhans/*immunology
- Logistic Models
- Male
- Prospective Studies
- Remission Induction
- Research Support; Non-U.S. Gov't
- Survival Analysis
- Time Factors
- Type 1 DM
- remission
- BMI
- islet antibodies
- young adults
- MEDICINE
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Schölin, Anna
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Törn, Carina
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Nyström, Lennart ...
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Berne, Christian
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Arnqvist, Hans, ...
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Blohme, G
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show more...
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Bolinder, J
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Eriksson, Jan W
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Kockum, I
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Landin-Olsson, M ...
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Östman, J
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Karlsson, F Ande ...
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Sundkvist, Göran
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Björk, Elisabeth
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetic Medicin ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet
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Lund University
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Linköping University