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Exploring the Antibacterial and Hemolytic Activity of Shorter- and Longer-Chain B-, a,B-, and y-Peptides, and of B-Peptides from B2-3-Aza- and B3-2-Methylidene-amino Acids Bearing Proteinogenic Side Chains - A Survey
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- Arvidsson, Per (author)
- Uppsala universitet,Kemiska institutionen,Organisk kemi I,Organisk kemi
- Ryder, Neil S. (author)
- Weiss, H. Markus (author)
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- Hook, David F. (author)
- Escalante, Jaime (author)
- Seebach, Dieter (author)
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- (creator_code:org_t)
- 2005
- 2005
- English.
- In: Chemistry & Biodiversity. ; 2, s. 401-420
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The antibacterial activities of 31 different b-, mixed a/B-, and y-peptides, as well as of B-peptides derived from B2-3-aza- and B3-2-methylidene-amino acids were assayed against six pathogens (Enterococcus faecails, STaphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa), and the results were compared with literature data. The interaction of these peptides with mammalian cells, as modeled by measuring the hemolysis of human erythrocytes, was also investigated. In addition to those peptides designed to fold into amphiphilic helical conformations with positive charges on one face of the helix, one new peptide with hemolytic activity was detected within the sample set. Moreover, it was demontrated that neither cationic peptides used for membrane translocation (B3-oligoarginines), nor mixeda/B- or y-peptides with somatostatin-mimicking activities display unwanted hemolytic activity.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Organic chemistry
- Organisk kemi
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- ref (subject category)
- art (subject category)
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- Arvidsson, Per
- Ryder, Neil S.
- Weiss, H. Markus
- Hook, David F.
- Escalante, Jaime
- Seebach, Dieter
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- NATURAL SCIENCES
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