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- Helmersson, JohannaUppsala universitet,Institutionen för folkhälso- och vårdvetenskap (author)
Cyclooxygenase-mediated prostaglandin F2alpha is decreased in an elderly population treated with low-dose aspirin
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Elsevier BV,2005
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-70195
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-70195URI
- https://doi.org/10.1016/j.plefa.2004.10.019DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Low-dose aspirin (acetylsalicylic acid) is used as prophylaxis against cardiovascular diseases. The effect of aspirin on inflammation and oxidative stress, processes known to be involved in cardiovascular diseases, are not fully known. Cyclooxygenase(COX)-mediated inflammatory indicator prostaglandin F2alpha(PGF2alpha (15-keto-dihydro-PGF2alpha), cytokine-mediated inflammatory indicators (interleukin-6, high sensitivity C-reactive protein, serum amyloid A protein), and oxidative stress indicators (8-iso-PGF2alpha, tocopherols) were quantified in men with daily 75 mg of aspirin (n = 175) and control men (n = 464), all of age 77, in a cross-sectional study. Men treated with aspirin had decreased levels of urinary 15-keto-dihydro-PGF2alpha than controls (P < 0.01), independent of possible cardiovascular risk factors. Aspirin-treated men had increased levels of alpha-tocopherol than controls (P<0.05). This is the first study to indicate that low-dose aspirin treatment is associated with decreased levels of PGF2alpha. This observation suggests a possible COX-mediated anti-inflammatory effect of low-dose aspirin, which should be further confirmed by intervention studies.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
- prostaglandin F2alpha
- isoprostan
- asprin
- acetylsalicylsyra
- human
- cyclooxygenase
- cytokines
- Dermatology and venerology,clinical genetics, internal medicine
- Dermatologi och venerologi, klinisk genetik, invärtesmedicin
Added entries (persons, corporate bodies, meetings, titles ...)
- Vessby, BengtUppsala universitet,Institutionen för folkhälso- och vårdvetenskap(Swepub:uu)bengvess (author)
- Larsson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Biokemisk struktur och funktion(Swepub:uu)andlarss (author)
- Basu, SamarUppsala universitet,Institutionen för folkhälso- och vårdvetenskap(Swepub:uu)samabasu (author)
- Uppsala universitetInstitutionen för folkhälso- och vårdvetenskap (creator_code:org_t)
Related titles
- In:Prostaglandins, Leukotrienes and Essential Fatty Acids: Elsevier BV72:4, s. 227-2330952-32781532-2823
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