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Nanoporous aluminum oxide affects neutrophil behaviour
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- Karlsson, M. (author)
- Uppsala universitet,Institutionen för ytbioteknik med Centrum för ytbioteknik,Oorganisk kemi,Institutionen för fysikalisk och analytisk kemi
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- Johansson, Anders (author)
- Uppsala universitet,Oorganisk kemi,oorganisk kemi
- Tang, L. (author)
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- 2004
- 2004
- English.
- In: Microscopy Research and Technique. ; 63:5, s. 259-265
- Journal article (peer-reviewed)
Abstract
Subject headings
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- This study evaluates neutrophil responses on aluminum oxide membranes. Using an in vitro cell culture system, we have found that the pore size (20 and 200 nm in diameter) of alumina membranes have a significant effect on leukocyte morphology and activation. Specifically, our results show that 20-nm pore-size membranes were more potent in triggering PMN spreading and extending of pseudopodia than 200-nm pore-size membranes. The morphological changes are also associated with cell activation. In fact, adherent neutrophils on 20-nm pore-size membranes elicit much stronger initial oxygen free radical production. Overall, our results point out that membrane pore size significantly affects the extent of cellular responses of adherent neutrophils.
Subject headings
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
Keyword
- polymorphonuclear leukocytes (PMN)
- activation
- morphology
- biomaterial
- surface topography
- Inorganic chemistry
- Oorganisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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