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Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome : prospective verification in the GUSTO-IV trial

James, Stefan (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
Armstrong, Paul (author)
Califf, Robert (author)
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Simoons, Maarten L. (author)
Venge, Per (author)
Uppsala universitet,Institutionen för medicinska vetenskaper
Wallentin, Lars (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
Lindahl, Bertil (author)
Uppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi
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 (creator_code:org_t)
2003
2003
English.
In: American Journal of Medicine. - 0002-9343 .- 1555-7162. ; 115:3, s. 178-184
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: A third-generation troponin T assay with improved precision and a lower detection limit has been developed. However, the appropriate cutoff for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality has not been established. METHODS: A retrospective evaluation of data from the Fragmin and fast Revascularization during InStability in Coronary artery disease II (FRISC-II) trial suggested that a cutoff below 0.1 microg/L for troponin T levels might be more useful in risk stratification. A prospective validation of two cutoff levels (0.03 microg/L and 0.01 microg/L) was performed in 7115 patients with non-ST-elevation acute coronary syndrome from the Global Utilization of Strategies To open Occluded arteries IV (GUSTO-IV) trial. RESULTS: Patients with troponin T levels >0.1 microg/L had greater 30-day mortality (5.5% [201/3679]) than did those with levels CONCLUSION: Using a cutoff of

Keyword

Acute Disease
Aged
Biological Markers/blood
Coronary Disease/*blood/epidemiology
Endpoint Determination/methods
Europe/epidemiology
Female
Humans
Male
Myocardial Infarction/epidemiology
North America/epidemiology
Outcome Assessment (Health Care)
Predictive Value of Tests
Prospective Studies
Reference Values
Research Support; Non-U.S. Gov't
Retrospective Studies
Sensitivity and Specificity
Survival Analysis
Syndrome
Troponin T/*blood
MEDICINE
MEDICIN

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