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Relative importance...
Relative importance of borderline and elevated levels of coronary heart disease risk factors.
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Vasan, Ramachandran S (author)
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Sullivan, Lisa M (author)
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Wilson, Peter W F (author)
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Sempos, Christopher T (author)
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- Sundstrom, Johan (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap
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Kannel, William B (author)
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Levy, Daniel (author)
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D'Agostino, Ralph B (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Ann Intern Med. - 1539-3704. ; 142:6, s. 393-402
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment. OBJECTIVE: To estimate the relative and absolute contributions of borderline and elevated risk factors to the population burden of coronary heart disease (CHD) events. DESIGN: A prospective cohort study and a national cross-sectional survey. SETTING: The Framingham Study and the Third National Health and Nutrition Examination Survey (NHANES III). PARTICIPANTS: White non-Hispanic persons in the Framingham Study and in NHANES III who were between 35 to 74 years of age and had no CHD. MEASUREMENTS: Occurrence of first CHD events according to 5 major CHD risk factors: blood pressure, low-density lipoprotein and high-density lipoprotein cholesterol levels, glucose intolerance, and smoking. Three categories-optimal, borderline, and elevated-were defined for each risk factor per national guidelines. Sex-specific 10-year CHD event rates from the Framingham Study were applied to numbers of at-risk individuals estimated from NHANES III and the 2000 U.S. Census. RESULTS: Twenty-six percent of men and 41% of women had at least 1 borderline risk factor in NHANES III. According to estimates, more than 90% of CHD events will occur in individuals with at least 1 elevated risk factor, and approximately 8% will occur in people with only borderline levels of multiple risk factors. Absolute 10-year CHD risk exceeded 10% in men older than age 45 years who had 1 elevated risk factor and 4 or more borderline risk factors and in those who had at least 2 elevated risk factors. In women, absolute CHD risk exceeded 10% only in those older than age 55 years who had at least 3 elevated risk factors. LIMITATIONS: The generalizability of the findings to persons of other ethnic backgrounds is unknown. CONCLUSIONS: Borderline CHD risk factors alone account for a small proportion of CHD events.
Keyword
- Adult
- Age Distribution
- Aged
- Blood Pressure/physiology
- Coronary Disease/*epidemiology/etiology/physiopathology
- Cross-Sectional Studies
- Female
- Glucose Intolerance/complications
- Humans
- Hypertension/complications
- Lipoproteins; HDL Cholesterol/blood
- Lipoproteins; LDL Cholesterol/blood
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sex Distribution
- Smoking/adverse effects
- United States/epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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