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  • Edlund, SofiaUppsala universitet,Ludwiginstitutet för cancerforskning (author)

Interaction between Smad7 and beta-catenin : importance for transforming growth factor beta-induced apoptosis

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • 2005
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-72728
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72728URI
  • https://doi.org/10.1128/MCB.25.4.1475-1488.2005DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Members of the transforming growth factor beta (TGF-beta) and Wnt/wingless superfamilies regulate cell fate during development and tissue maintenance. Here we report that Smad7 interacts with beta-catenin and lymphoid enhancer binding factor 1/T-cell-specific factor (LEF1/TCF), transcriptional regulators in Wnt signaling, in a TGF-beta-dependent manner. Smad7 was found to be required for TGF-beta1-induced accumulation of beta-catenin and LEF1 in human prostate cancer (PC-3U) cells as well as in human keratinocytes (HaCaT cells). Moreover, when the endogenous Smad7 was repressed by specific small interfering RNA, TGF-beta-induced increase of activated p38, Akt phosphorylated on Ser473, glycogen synthase kinase 3beta phosphorylated on Ser9 was prevented, as well as the TGF-beta-induced association between beta-catenin and LEF1. Notably, the observed physical association of Smad7 and beta-catenin was found to be important for TGF-beta-induced apoptosis, since suppression of beta-catenin expression by small interfering RNA decreased the apoptotic response to TGF-beta.

Subject headings and genre

  • Animals
  • Apoptosis/drug effects/*physiology
  • COS Cells
  • Cell Fractionation
  • Cercopithecus aethiops
  • Cytoskeletal Proteins/*metabolism
  • DNA-Binding Proteins/*metabolism
  • Glycogen Synthase Kinase 3/metabolism
  • Humans
  • Male
  • Mice
  • Phosphorylation/drug effects
  • Prostatic Neoplasms/metabolism
  • Protein Binding/drug effects
  • Protein-Serine-Threonine Kinases/metabolism
  • Proto-Oncogene Proteins/metabolism
  • RNA; Small Interfering/metabolism
  • Research Support; Non-U.S. Gov't
  • Serine/metabolism
  • Trans-Activators/*metabolism
  • Transcription Factors/*metabolism
  • Transforming Growth Factor beta/*pharmacology
  • Tumor Cells; Cultured
  • p38 Mitogen-Activated Protein Kinases/metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lee, So YoungUppsala universitet,Ludwiginstitutet för cancerforskning (author)
  • Grimsby, SusanneUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)susagrim (author)
  • Zhang, ShouthingUppsala universitet,Ludwiginstitutet för cancerforskning (author)
  • Aspenström, PontusUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)pontaspe (author)
  • Heldin, Carl-HenrikUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)carlheld (author)
  • Landström, MaréneUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)mareland (author)
  • Uppsala universitetLudwiginstitutet för cancerforskning (creator_code:org_t)

Related titles

  • In:Molecular and Cellular Biology25:4, s. 1475-14880270-73061098-5549

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