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Revascularization o...
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
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Li, Xuri (author)
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Tjwa, Marc (author)
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Moons, Lieve (author)
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Fons, Pierre (author)
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Noel, Agnes (author)
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Ny, Annelii (author)
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Zhou, Jian Min (author)
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- Lennartsson, Johan (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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Li, Hong (author)
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Luttun, Aernout (author)
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Pontén, Annica (author)
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Devy, Laetitia (author)
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Bouché, Ann (author)
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Oh, Hideyasu (author)
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Manderveld, Ann (author)
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Blacher, Silvia (author)
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Communi, David (author)
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Savi, Pierre (author)
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Bono, Françoise (author)
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Dewerchin, Mieke (author)
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Foidart, Jean-Michel (author)
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Autiero, Monica (author)
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Herbert, Jean-Marc (author)
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Collen, D (author)
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- Heldin, Carl-Henrik (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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Eriksson, Ulf (author)
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Carmeliet, Peter (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Journal of Clinical Investigation. - 0021-9738 .- 1558-8238. ; 115:1, s. 118-127
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Keyword
- Animals
- Cell Differentiation/drug effects
- Cell Movement/drug effects
- Cells; Cultured
- Coronary Vessels/cytology/drug effects
- Endothelial Cells/*cytology/*drug effects
- Hindlimb/blood supply/drug effects
- Humans
- Ischemia/chemically induced/*drug therapy/metabolism/*pathology
- Mice
- Microcirculation/drug effects
- Myocardium/metabolism/pathology
- Neovascularization; Physiologic/*drug effects
- Phosphotyrosine/metabolism
- Platelet-Derived Growth Factor/*pharmacology
- Receptors; Platelet-Derived Growth Factor/metabolism
- Research Support; Non-U.S. Gov't
- Signal Transduction
- Stem Cells/cytology/*drug effects
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Li, Xuri
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Tjwa, Marc
-
Moons, Lieve
-
Fons, Pierre
-
Noel, Agnes
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Ny, Annelii
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show more...
-
Zhou, Jian Min
-
Lennartsson, Joh ...
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Li, Hong
-
Luttun, Aernout
-
Pontén, Annica
-
Devy, Laetitia
-
Bouché, Ann
-
Oh, Hideyasu
-
Manderveld, Ann
-
Blacher, Silvia
-
Communi, David
-
Savi, Pierre
-
Bono, Françoise
-
Dewerchin, Mieke
-
Foidart, Jean-Mi ...
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Autiero, Monica
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Herbert, Jean-Ma ...
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Collen, D
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Heldin, Carl-Hen ...
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Eriksson, Ulf
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Carmeliet, Peter
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show less...
- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University