Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

Amides/*chemical synthesis/chemistry/pharmacology

Animals

Aspartic Endopeptidases/*antagonists & inhibitors/chemistry

Cathepsin D/*antagonists & inhibitors

Cells; Cultured

Computer Simulation

Erythrocytes/parasitology

Ethylenes/*chemistry

Humans

Models; Molecular

Molecular Conformation

Plasmodium falciparum/drug effects/*enzymology

Protein Binding

Research Support; Non-U.S. Gov't

Stereoisomerism

Structure-Activity Relationship

Thermodynamics

PHARMACY

FARMACI

NATURAL SCIENCES

NATURVETENSKAP

Biochemistry

Publication and Content Type

ref (subject category)

art (subject category)