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- Ärnlöv, JohanUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics (author)
Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly men
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- Oxford University Press (OUP),2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-72760
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72760URI
- https://doi.org/10.1016/j.ehj.2004.10.021DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- AIMS: There is limited data on echocardiographic and Doppler indices of cardiac function as predictors for congestive heart failure (CHF) in the general population. Myocardial performance index (MPI, also denoted TEI-Doppler index) reflects both left ventricular (LV) systolic and diastolic function. METHODS AND RESULTS: We compared eight different echocardiographic and Doppler indices of cardiac function as predictors of CHF using a population-based cohort of 552 seventy-year-old men without CHF and significant valve disease at baseline (median follow-up time 8.2 years). In a stepwise multivariable Cox proportional-hazard analysis including the different indices of cardiac function, high MPI (above the 90th percentile of MPI [> or =0.91]), abnormal LV wall motion score index and a pseudo-normalized/restrictive E/A-ratio pattern independently predicted future CHF morbidity. After adding traditional CHF risk factors (age, previous myocardial infarction, hypertension, diabetes mellitus, hyperlipidaemia, smoking, LV hypertrophy and body mass index) to the above model, only a high MPI remained a significant predictor (hazard ratio 4.72, 95% CI 1.75-12.76, p=0.002). CONCLUSION: MPI provides important prognostic information for the risk of future CHF, beyond other measurements of cardiac function and traditional heart failure risk factors in elderly men. MPI seems to be a clinically relevant indicator of cardiac function and may prove to be a valuable tool in assessing the risk of future CHF.
Subject headings and genre
- Aged
- Cohort Studies
- Diabetic Angiopathies/etiology/physiopathology/ultrasonography
- Echocardiography; Doppler/*methods
- Follow-Up Studies
- Heart Failure; Congestive/*etiology/physiopathology/prevention & control
- Humans
- Hyperlipidemia/complications/physiopathology
- Hypertension/complications/physiopathology
- Male
- Prognosis
- Research Support; Non-U.S. Gov't
- Risk Factors
- Smoking/adverse effects
- Ventricular Dysfunction; Left/physiopathology/*ultrasonography
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Ingelsson, ErikUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics(Swepub:uu)ering425 (author)
- Risérus, UlfUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition(Swepub:uu)ulfriser (author)
- Andrén, BertilUppsala universitet,Institutionen för medicinska vetenskaper,Kardiologi(Swepub:uu)bertand (author)
- Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)larslind (author)
- Uppsala universitetInstitutionen för folkhälso- och vårdvetenskap (creator_code:org_t)
Related titles
- In:European Heart Journal: Oxford University Press (OUP)25:24, s. 2220-22250195-668X1522-9645
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