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Impaired endotheliu...
Impaired endothelium-dependent vasodilatation in renal failure in humans
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- Annuk, Margus (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Linde, Torbjörn (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Fellström, Bengt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2001-02
- 2001
- English.
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In: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 16:2, s. 302-306
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: The main causes of death in patients with chronic renal failure (CRF) are cardiovascular complications. The aim of the present study was to compare endothelium-dependent vasodilatation (EDV) in patients with chronic renal failure with a control population controlling for hypertension, diabetes mellitus and hypercholesterolaemia. METHODS: Fifty-six patients with moderate CRF (mean creatinine clearance 29.4 ml/min/1.73 m(2)) underwent evaluation of EDV and endothelium-independent vasodilatation (EIDV) by means of forearm blood flow (FBF) measurements with venous occlusion plethysmography during local intra-arterial infusions of methacholine (Mch, 2 and 4 microg/min evaluating EDV) and sodium nitroprusside (SNP, 5 and 10 microg/min evaluating EIDV). Fifty-six control subjects without renal impairment underwent the same investigation. RESULTS: Infusion of Mch increased FBF significantly less in patients with renal failure than in controls (198 vs 374%, P<0.001), whereas no significant difference was seen regarding the vasodilatation induced by SNP (278 vs 269%). The differences in EDV between the groups were still significant after controlling for hypertension, blood glucose, and serum cholesterol in multiple regression analysis (P<0.001). EDV was related to serum creatinine (r=-0.37, P<0.01), creatinine clearance (r=0.45, P<0.005) and to serum triglyceride levels (r=-0.29, P<0.005) in the CRF group. CONCLUSIONS: Patients with moderate CRF have an impaired EDV even after correction for traditional cardiovascular risk factors and this impairment is related to the degree of renal failure.
Keyword
- Aged
- Creatinine/blood
- Endothelium; Vascular/*physiopathology
- Female
- Forearm/blood supply
- Humans
- Injections; Intra-Arterial
- Kidney Failure; Chronic/*physiopathology
- Male
- Methacholine Chloride/pharmacology
- Middle Aged
- Nitroprusside/pharmacology
- Plethysmography
- Reference Values
- Regional Blood Flow/drug effects
- Research Support; Non-U.S. Gov't
- Vasodilation
- Veins
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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