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Polymorphisms in th...
Polymorphisms in the renin-angiotensin system and endothelium-dependent vasodilation in normotensive subjects
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- Kurland, Lisa, 1960- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Medical Sciences, Uppsala University Hospital, Sweden; Department of Medicine, University Hospital, Uppsala, Sweden
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- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis,Department of Medical Sciences, Uppsala University Hospital, Sweden
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- Sarabi, Mahziar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Medical Sciences, Uppsala University Hospital, Sweden
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- Millgård, Jonas (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Medical Sciences, Uppsala University Hospital, Sweden
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- Ljunghall, Sverker (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Uppsala University Hospital, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Medical Sciences, Uppsala University Hospital, Sweden
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(creator_code:org_t)
- 2008-06-28
- 2001
- English.
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In: Clinical Physiology. - : Wiley. - 0144-5979 .- 1365-2281. ; 21:3, s. 343-349
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Abstract
Subject headings
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- BACKGROUND: Our aim was to test the hypothesis that genes encoding components in the renin-angiotensin system influence endothelial vasodilatory function. METHODS: In 59 apparently healthy, normotensive individuals, endothelium-dependent vasodilation (EDV) and endothelial-independent vasodilation (EIDV) was evaluated by infusing metacholine and sodium nitroprusside into the brachial artery. Forearm blood flow was measured by venous occlusion plethysmography. The ACE insertion (I)/deletion (D) polymorphism, the T174M and M235T angiotensinogen restriction fragments length polymorphisms, the angiotensin II receptor type 1 (AT1R) A1166C, and the aldosterone synthase gene (CYP11B2) C-344T polymorphisms were analysed. RESULTS: When analysing the ACE, the two angiotensinogen and the aldosterone synthase CYP11B2 genotypes independently, no significant association with endothelial vasodilatory function was found. However, a significant reduction in endothelium-dependent vasodilation was observed in the subjects (n=9) with the ACE D allele and the angiotensinogen T174M genotype (P<0.05). Subjects with the AT1R genotype AC showed a reduction in both EDV (P=0.05) and EIDV (P=0.04) when compared with those with the AA genotype. CONCLUSIONS: The subjects with the ACE D allele in combination with the angiotensinogen T174M genotype are associated with a reduced EDV. This together with the observation that the AC AT1R genotype is associated with a reduction in both EDV and EIDV, supports the hypothesis that endothelial vasodilatory function is influenced by genes in the renin-angiotensinogen system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Adult
- Aged
- Aldosterone Synthase/genetics
- Endothelium
- Vascular/*physiology
- Female
- Gene Deletion
- Humans
- Male
- Middle Aged
- Nitroprusside/administration & dosage/pharmacology
- Peptidyl-Dipeptidase A/*genetics
- Polymorphism; Genetic
- Polymorphism
- Restriction Fragment Length
- Receptor
- Angiotensin
- Type 1; Receptor; Angiotensin; Type 2
- Receptors; Angiotensin/genetics
- Renin-Angiotensin System/*genetics
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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