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Blood flow is an im...
Blood flow is an important determinant of forearm glucose uptake following a mixed meal
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- Fugmann, Andreas (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Sarabi, Mahziar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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- Karlström, Brita (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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- Berne, Christian (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lithell, Hans (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2003
- 2003
- English.
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In: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 40:3, s. 113-117
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Insulin-mediated vasodilation has been suggested to be of importance for glucose uptake during normoglycemic hyperinsulinemia. If this also is valid after an ordinary mixed meal remains to be evaluated. Forearm blood flow (FBF) and forearm glucose uptake change (evaluated by venous occlusion plethysmography) and glucose arteriovenous differences were evaluated over 120 minutes in 10 healthy volunteers following an ordinary mixed meal (700-900 kcal, 34% of energy from fat). Fasting arterial glucose level was 4.9+/-0.9 mmol/l, and the maximum glucose level was reached 30 minutes after the start of ingestion (6.6+/-0.8 mmol/l, p<0.0001). Plasma insulin levels were increased four-fold. FBF increased rapidly within 20 minutes after the start of ingestion and reached its maximum after 50 minutes (94% higher than baseline level, p<0.01). After 2 hours FBF was still substantially elevated (75% above baseline level, p<0.01). Forearm glucose uptake increased fivefold already after 20 minutes ( p<0.01). During the 2 hours, the increase in FBF contributed to 41% of the forearm glucose uptake ( p<0.05). The present study showed that the increase in FBF seen after an ordinary mixed meal is important for the change in forearm glucose uptake. These results support the view that modulation of limb blood flow is a determinant of glucose uptake.
Keyword
- Adult
- Blood Glucose/*metabolism
- Blood Pressure
- Fatty Acids; Nonesterified/blood
- Forearm/*blood supply
- Glucose/*metabolism
- Humans
- Insulin/blood
- Kinetics
- Oxygen Consumption
- Plethysmography
- Postprandial Period
- Reference Values
- Regional Blood Flow/*physiology
- Time Factors
- Triglycerides/blood
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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