Search: onr:"swepub:oai:DiVA.org:uu-73330" >
Smad regulation in ...
Smad regulation in TGF-beta signal transduction
-
- Moustakas, Aristidis (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
-
- Souchelnytskyi, Serhiy (author)
- Karolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning
-
- Heldin, Carl-Henrik (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
-
(creator_code:org_t)
- The Company of Biologists, 2001
- 2001
- English.
-
In: Journal of Cell Science. - : The Company of Biologists. - 0021-9533 .- 1477-9137. ; 114:Pt 24, s. 4359-4369
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Smad proteins transduce signals from transforming growth factor-beta (TGF-beta) superfamily ligands that regulate cell proliferation, differentiation and death through activation of receptor serine/threonine kinases. Phosphorylation of receptor-activated Smads (R-Smads) leads to formation of complexes with the common mediator Smad (Co-Smad), which are imported to the nucleus. Nuclear Smad oligomers bind to DNA and associate with transcription factors to regulate expression of target genes. Alternatively, nuclear R-Smads associate with ubiquitin ligases and promote degradation of transcriptional repressors, thus facilitating target gene regulation by TGF-beta. Smads themselves can also become ubiquitinated and are degraded by proteasomes. Finally, the inhibitory Smads (I-Smads) block phosphorylation of R-Smads by the receptors and promote ubiquitination and degradation of receptor complexes, thus inhibiting signalling.
Keyword
- Activin Receptors; Type I/*metabolism/physiology
- Animals
- DNA-Binding Proteins/physiology
- Humans
- Phosphoproteins/physiology
- Receptor Protein-Tyrosine Kinases/*metabolism/physiology
- Receptors; Transforming Growth Factor beta/*metabolism/physiology
- Research Support; Non-U.S. Gov't
- Signal Transduction/*physiology
- Trans-Activators/physiology
- Transforming Growth Factor beta/*physiology
Publication and Content Type
- vet (subject category)
- for (subject category)
Find in a library
To the university's database