Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets : possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

Keyword

ABO Blood-Group System

Aged

Aged; 80 and over

Anticoagulants/therapeutic use

Antigens; CD11/analysis

Blood Platelets/pathology

Cadaver

Female

Fibrin/physiology

Glycine/*analogs & derivatives/*therapeutic use

Humans

Immunohistochemistry

Inflammation/*blood/pathology/*prevention & control

Islets of Langerhans/*physiopathology

Islets of Langerhans Transplantation

Male

Middle Aged

Neutrophils/pathology

Platelet Glycoprotein GPIIb-IIIa Complex/analysis

Research Support; Non-U.S. Gov't

Thrombin/*antagonists & inhibitors

Thrombosis/blood/pathology/prevention & control

Publication and Content Type

ref (subject category)

art (subject category)