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- Lehmann, SörenKarolinska Institutet (author)
The expression of cellular retinoid binding proteins in non-APL leukemic cells and its association with retinoid sensitivity
- Article/chapterEnglish2002
Publisher, publication year, extent ...
- 2009-07
- Informa UK Limited,2002
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-73707
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73707URI
- https://doi.org/10.1080/10428190290016999DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1955625URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Retinoic acid (RA) has important effects on cell differentiation and cell growth and on normal embryonic development. Intracellular retinoid signaling induced by endogenous or exogenous RA is regulated by retinoid binding proteins such as CRBPI, CRABPI and CRABPII and there are data suggesting that the expression of these proteins can influence the sensitivity to the growth inhibitory effects of ATRA. In this study, we investigated the basal and ATRA-induced expression of CRBPI and CRABPI and II in leukemic cell lines and in cells from patients with acute myeloid leukemia (AML). CRBPI as well as CRABPI and II were expressed in all tested cell lines and in leukemic cells from all 18 AML-patients. CRABPII mRNA expression was more abundant than CRBPI and CRABPI in both the cell lines and the patient cells but the levels compared the house keeping gene was lower in the patient cells. In all cell lines and in 69% of the patient samples, ATRA did upregulate CRABPII whereas CRBPI exhibited a varying response and CRABPI was more commonly downregulated. The sensitivity to the growth inhibitory effects of ATRA did not correlate with the basal expression of any of these proteins. However, ATRA-induced upregulation of CRABPII did significantly correlate with the ATRA sensitivity (p < 0.005) as well as with ATRA-induced upregulation of the retinoid receptor RARbeta (p < 0.05). We conclude that the retinoid binding proteins CRBPI and CRABPI and II are expressed in myeloid leukemic cells of non-M3 type but that the level of expression does not affect ATRA sensitivity.
Subject headings and genre
- Gene Expression
- Humans
- Leukemia/drug therapy/*metabolism
- RNA; Messenger/analysis
- Receptors; Retinoic Acid/analysis/*genetics
- Research Support; Non-U.S. Gov't
- Retinol-Binding Proteins/analysis/*genetics
- Tretinoin/*therapeutic use
- Tumor Cells; Cultured
- Up-Regulation
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Paul, CristerKarolinska Institutet (author)
- Törmä, HansUppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi(Swepub:uu)hanstorm (author)
- Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Related titles
- In:Leukemia and Lymphoma: Informa UK Limited43:4, s. 851-81042-81941029-2403
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