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Type 1 diabetes is ...
Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation
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- Basu, Samar (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Larsson, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Vessby, Johan (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Vessby, Bengt (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Berne, Christian (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi
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(creator_code:org_t)
- American Diabetes Association, 2005
- 2005
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 28:6, s. 1371-1375
- Related links:
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http://www.ncbi.nlm....
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http://care.diabetes...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- OBJECTIVE: The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type 1 diabetes is not fully understood. RESEARCH DESIGN AND METHODS: Plasma high-sensitivity C-reactive protein (CRP), 24-h urinary and plasma 15-keto-dihydro-prostaglandin F(2alpha) (a metabolite of prostaglandin F(2alpha) [PGF(2alpha)] and an indicator of COX-mediated inflammation), serum amyloid protein A (SAA), and interleukin (IL)-6 (indicators of inflammation) were measured in 38 subjects with type 1 diabetes and 41 healthy age- and sex-matched control subjects. RESULTS: The inflammatory indicators (urinary 15-keto-dihydro-PGF(2alpha), P < 0.01; IL-6, P < 0.04) were increased in men with diabetes. CRP and SAA did not show any significant difference between the diabetic and the control subjects. Urinary levels of 15-keto-dihydro-PGF(2alpha) correlated with the degree of glycemic control, HbA(1c) (r = 0.42, P < 0.0005). No correlation was found between the duration of diabetes and the inflammatory biomarkers or metabolic measurements. CONCLUSIONS: These results suggest that an early low-grade inflammatory process reflected by elevated levels of PGF(2alpha) and IL-6 is involved in type 1 diabetes. Thus, both COX- and cytokine-mediated inflammatory pathways are significantly related to type 1 diabetes.
Keyword
- Adult
- Albuminuria/epidemiology
- C-Reactive Protein/*analysis
- Cytokines/blood
- Diabetes Mellitus; Type 1/blood/*complications/*physiopathology
- Diabetic Angiopathies/epidemiology
- Dinoprost/analogs & derivatives/blood
- Female
- Humans
- Hypertension/epidemiology
- Inflammation/*epidemiology
- Lipids/blood
- Male
- Reference Values
- Regression Analysis
- Research Support; Non-U.S. Gov't
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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