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- Carlson, MarieUppsala universitet,Institutionen för medicinska vetenskaper,Gastro (author)
Degranulation of eosinophils from pollen-atopic patients with asthma is increased during pollen season
- Article/chapterEnglish1992
Publisher, publication year, extent ...
- 1992
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-74323
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-74323URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The secretion of granule proteins from eosinophils and neutrophils was studied in isolated cells, obtained from 11 pollen-atopic patients with asthma, twice during and twice outside pollen season. Granulocytes were stimulated with serum-opsonized Sephadex particles, and the released amount of eosinophil cationic protein (ECP), eosinophil protein X (EPX), and myeloperoxidase (MPO) were measured by means of specific radioimmunoassay (RIA). Eosinophils from the pollen-atopic patients obtained during pollen season released significantly more (p less than 0.02) ECP and EPX than cells from the same patients obtained before pollen season. The released amount of ECP and EPX was correlated (r = 0.54; p less than 0.003) to the total pollen count. The release of MPO from neutrophils was only raised (p less than 0.01) at the end of the pollen season. Serum concentrations of ECP and EPX and blood eosinophil counts were significantly raised (p less than 0.002, p less than 0.001, and p less than 0.009, respectively) before pollen season and increased further at the end of the pollen season. There were no changes in lung function during pollen season and consequently no discernible relationships to eosinophil and neutrophil degranulation. We conclude that eosinophils and, to some extent, neutrophils from birch pollen-atopic subjects have an increased propensity to secrete their granule proteins during a pollen season. We suggest that these cells have been primed as a consequence of allergen exposure.
Subject headings and genre
- Adolescent
- Adult
- Asthma/*blood/therapy
- Blood Proteins/analysis
- Cell Degranulation
- Eosinophil Granule Proteins
- Eosinophils/*physiology
- Female
- Humans
- Hypersensitivity/*blood
- Interleukin-5/physiology
- Leukocyte Count
- Male
- Middle Aged
- Neutrophils/physiology
- Peroxidase/analysis
- Pollen/*immunology
- Research Support; Non-U.S. Gov't
- Ribonucleases
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Håkansson, LenaUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)lenadouh (author)
- Kämpe, MaryUppsala universitet,Lungmedicin och allergologi(Swepub:uu)marykamp (author)
- Stålenheim, GunnemarUppsala universitet,Lungmedicin och allergologi(Swepub:uu)gunnstal (author)
- Peterson, ChristerUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)chpet425 (author)
- Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper,Inflammation(Swepub:uu)pervenge (author)
- Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Related titles
- In:Journal of Allergy and Clinical Immunology89:1 Pt 1, s. 131-1390091-67491097-6825
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