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- Axelsson, JohnKarolinska Institutet (author)
Effects of acutely displaced sleep on testosterone.
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- The Endocrine Society,2005
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-75447
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-75447URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1957269URI
- https://doi.org/10.1210/jc.2005-0520DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
Classification
Notes
- CONTEXT: It is not yet clear whether the diurnal variation in testosterone is regulated by circadian or homeostatic (sleep) influences. OBJECTIVE: The present study tested whether testosterone is driven by a circadian-independent sleep effect by shifting sleep acutely to daytime in a 24-h sampling regiment. DESIGN, SETTING, AND PARTICIPANTS: In the sleep laboratory, seven healthy young men (age, 22-32 yr) participated in three conditions: habituation (sleep between 2300-0700 h), night sleep (2300-0700 h), and day sleep (0700-1500 h), the latter two in a balanced order. INTERVENTION AND MAIN OUTCOME MEASURE: Serum testosterone was, in all conditions, sampled by hourly blood drawing for 24 h during constant bed rest. RESULTS: Mean testosterone levels increased as a log-linear function of time (hours) across both sleep periods (b = 4.88; P < 0.001), from 15.3 +/- 2.1 to 25.3 +/- 2.2 nmol/liter during night sleep and from 17.3 +/- 2.1 to 26.4 +/- 2.9 nmol/liter during day sleep. Similarly, mean testosterone levels decreased with time (log-linear) awake (b = -1.80; P < 0.001). There was also evidence of a weak circadian component (acrophase ranging between 0651-0924 h) and an increase with time in the laboratory. Moreover, all these effects, except for the increase during sleep, differed significantly between individuals. CONCLUSION: In conclusion, testosterone increased during sleep and fell during waking, whereas circadian effects seemed marginal. Individual differences were pronounced.
Subject headings and genre
- Adult
- Circadian Rhythm/*physiology
- Humans
- Male
- Regression Analysis
- Research Support; Non-U.S. Gov't
- Sleep/*physiology
- Testosterone/*blood
- Wakefulness/*physiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Ingre, Michael (author)
- Åkerstedt, TorbjörnKarolinska Institutet (author)
- Holmbäck, UlfUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Institutionen för medicinska vetenskaper(Swepub:uu)ulfholmb (author)
- Karolinska InstitutetInstitutionen för folkhälso- och vårdvetenskap (creator_code:org_t)
Related titles
- In:J Clin Endocrinol Metab: The Endocrine Society90:8, s. 4530-50021-972X1945-7197
Internet link
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15914523&dopt=Citation
- https://academic.oup.com/jcem/article-pdf/90/8/4530/10817875/jcem4530.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-75447
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1957269
- https://doi.org/10.1210/jc.2005-0520
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