Design and synthesis of potent inhibitors of plasmepsin I and II : X-ray crystal structure of inhibitor in complex with plasmepsin II.

Keyword

Animals

Antiprotozoal Agents/*chemical synthesis/chemistry/*pharmacology

Aspartic Endopeptidases/*antagonists & inhibitors/*chemistry

Crystallography; X-Ray

Magnetic Resonance Spectroscopy

Models; Molecular

Molecular Conformation

Plasmodium falciparum/drug effects/*enzymology

Research Support; Non-U.S. Gov't

Structure-Activity Relationship

Publication and Content Type

ref (subject category)

art (subject category)